{
  "abstract": "Purpose Opioid use in pediatric oncology is poorly characterized. The primary objective was to describe opioid administration or prescription patterns in pediatric oncology patients. Methods In this multi‐center retrospective study conducted across three sites, we included patients aged 0–19 years with a malignant neoplastic disease who received their first chemotherapy between January 2019 and March 2024. Data were extracted from each site's Observational Medical Outcomes Partnership Common Data Model. We described patient characteristics based on: (1) first opioid administration or prescription, overall and for each specific opioid; and (2) all opioid administrations or prescriptions, overall and for each specific opioid. We also evaluated variability in opioid and naloxone use. Results Of 2903 pediatric patients with cancer, 2707 (93.2%) were administered or prescribed at least one opioid. Among these patients, fentanyl was the most common (92.4%), followed by morphine (68.7%), hydromorphone (55.3%), and oxycodone (38.6%). Across centers, the proportion of patients receiving fentanyl ranged from 90.9% to 94.9%, morphine from 34.0% to 89.2%, oxycodone from 0.9% to 76.1%, and naloxone from 2.4% to 29.5%. Overall, 10.9% were administered or prescribed naloxone, but among 169 methadone patients, 43.5% were administered or prescribed it. Of the 153,849 total opioid administrations or prescriptions, 22.4% occurred more than 12 months after initiating chemotherapy. Conclusions Among pediatric patients with cancer who receive chemotherapy, 93.2% were administered or prescribed at least one opioid; fentanyl was the most common. There was heterogeneity in opioid choice and naloxone use across sites. These findings lay preliminary groundwork for understanding opioid use patterns and identifying potential areas for practice improvement in pediatric oncology.",
  "abstract_shown": true,
  "affiliations": [
    "Child Health Evaluative Sciences The Hospital for Sick Children Toronto Ontario Canada",
    "Department of Pediatrics Stanford University School of Medicine Palo Alto California USA",
    "Columbia University School of Nursing/Herbert Irving Cancer Center New York New York USA",
    "Ben Towne Center for Childhood Cancer and Blood Disorders Research, Department of Pediatrics Seattle Children's Hospital, University of Washington Seattle Washington USA",
    "Department of Pediatrics Columbia University Irving Medical Center New York New York USA",
    "Data Sciences Unit Columbia University New York New York USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuqing Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "Martin Yi"
    },
    {
      "affs": [
        1
      ],
      "name": "Catherine C. Aftandilian"
    },
    {
      "affs": [
        2
      ],
      "name": "Melissa P. Beauchemin"
    },
    {
      "affs": [
        1
      ],
      "name": "Christine Cunningham"
    },
    {
      "affs": [
        2
      ],
      "name": "David DeStephano"
    },
    {
      "affs": [
        2
      ],
      "name": "Rhea K. Khurana"
    },
    {
      "affs": [
        3
      ],
      "name": "Emily Larimer"
    },
    {
      "affs": [
        4
      ],
      "name": "Jennifer Oberg"
    },
    {
      "affs": [
        4
      ],
      "name": "Benjamin L. May"
    },
    {
      "affs": [
        1
      ],
      "name": "Keith Morse"
    },
    {
      "affs": [
        5
      ],
      "name": "Karthik Natarajan"
    },
    {
      "affs": [
        3
      ],
      "name": "David Noyd"
    },
    {
      "affs": [
        3
      ],
      "name": "Victoria Soucek"
    },
    {
      "affs": [
        0
      ],
      "name": "Yujie Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Adam Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Lin Lawrence Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Lillian Sung"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ad10qwxcj9vv1.bib",
  "cited_by": 0,
  "doi": "10.1002/cam4.72310",
  "fulltext_url": "https://doi.org/10.1002/cam4.72310",
  "id": "ad10qwxcj9vv1",
  "issns": [
    "2045-7634"
  ],
  "landing_url": "https://doi.org/10.1002/cam4.72310",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "2703|Pain Management and Opioid Use"
    ]
  ],
  "openalex": "W7214736612",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/ad10qwxcj9vv1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:27Z",
      "native_id": "141bfd4375bf48d3a33ce26763637b9c",
      "source": "doaj",
      "url": "https://doi.org/10.1002/cam4.72310"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2703|Pain Management and Opioid Use",
      "subfield": "surgery"
    }
  ],
  "title": "Multi‐Center Evaluation of Opioid Administration or Prescription in Pediatric Oncology Patients Using the OMOP CDM",
  "title_text": "Multi‐Center Evaluation of Opioid Administration or Prescription in Pediatric Oncology Patients Using the OMOP CDM",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:27Z",
  "url": "https://research.draconitic.com/paper/ad10qwxcj9vv1",
  "venue": "Cancer Medicine",
  "versions": []
}