{
  "abstract": "Purpose: The WHO classification of head and neck tumors over the past five decades were reviewed, highlighting the major conceptual and taxonomic changes that have shaped contemporary head and neck pathology.\n\nMethods: Major WHO classifications of head and neck tumors were reviewed, with a focus on changes in diagnostic concepts and taxonomic principles rather than individual additions or removals of tumor entities.\n\nResults: WHO classifications have evolved from morphology-based, site-specific systems to an integrated clinicopathological and molecular taxonomy. Early editions emphasized histomorphology and presumed tissue of origin. Subsequent classifications, however, increasingly incorporated immunophenotypic and molecular findings. The recognition of virus-associated neoplasms and recurrent molecular alterations has contributed to defining new entities and refining existing categories. The fifth edition further standardized tumor taxonomy by introducing essential and desirable diagnostic criteria, reflecting a biology-driven approach to classification.\n\nConclusion: The evolution of WHO classifications reflects major advances in tumor biology and has substantially influenced diagnostic practice and clinical interpretation. Future classifications will likely incorporate increasingly sophisticated molecular, digital, and computational approaches while maintaining standardized, reproducible, and clinically meaningful diagnostic criteria.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, 126 - Cidade Universitária, Campinas, SP 13083-887 Brazil",
    "Oral Diagnosis Department, Piracicaba Dental School, Universidade Estadual de Campinas (FOP-UNICAMP), Piracicaba, SP Brazil",
    "Section of Pathology, Department of Translational Research, University of Pisa, Pisa, Italy",
    "Department of Pathology, Hospital Clinic, Barcelona, Spain",
    "Department of Basic Clinical Practice, School of Medicine, Universitat de Barcelona, Barcelona, Spain",
    "Department of Pathology, University of Calgary, Calgary, AB Canada",
    "Institute of Biomedicine, Pathology, Department of Pathology, University of Turku, Turku University Hospital, Turku, Finland",
    "Bioptic Laboratory, Ltd, Pilsen, Czech Republic",
    "Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic",
    "Coordinator of the International Head and Neck Scientific Group, Padua, Italy"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fernanda Viviane Mariano",
      "orcid": "0000-0003-3694-5025"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Luccas Lavareze",
      "orcid": "0000-0003-3464-8879"
    },
    {
      "affs": [
        0
      ],
      "name": "Arthur Antolini-Tavares",
      "orcid": "0000-0001-5964-4407"
    },
    {
      "affs": [
        2
      ],
      "name": "Alessandro Franchi",
      "orcid": "0000-0002-1332-5838"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Alfons Nadal",
      "orcid": "0000-0002-5366-093X"
    },
    {
      "affs": [
        5
      ],
      "name": "Roderick Simpson"
    },
    {
      "affs": [
        6
      ],
      "name": "Ilmo Leivo",
      "orcid": "0000-0002-9609-1597"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Martina Bradová",
      "orcid": "0000-0002-5829-5572"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Alena Skálová"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Reydson Alcides de Lima-Souza",
      "orcid": "0000-0001-5045-6960"
    },
    {
      "affs": [
        9
      ],
      "name": "Alfio Ferlito"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ad5nhwnxggazk.bib",
  "cited_by": 0,
  "doi": "10.1007/s12105-026-01962-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710733/",
  "id": "ad5nhwnxggazk",
  "issns": [
    "1936-055X",
    "1936-0568"
  ],
  "landing_url": "https://doi.org/10.1007/s12105-026-01962-8",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7223669487",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s12105-026-01962-8.pdf",
  "pmcid": "PMC13710733",
  "pmid": "42931985",
  "published": "2026-10-26",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/ad5nhwnxggazk.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:38Z",
      "native_id": "PMC13710733",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s12105-026-01962-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Head and Neck Cancer Studies",
      "subfield": "general"
    }
  ],
  "title": "The Historical Evolution of Head and Neck Tumor Pathology in WHO Classifications: From Morphology to Molecular Taxonomy",
  "title_text": "The Historical Evolution of Head and Neck Tumor Pathology in WHO Classifications: From Morphology to Molecular Taxonomy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:38Z",
  "url": "https://research.draconitic.com/paper/ad5nhwnxggazk",
  "venue": "Head and Neck Pathology",
  "versions": []
}