{
  "abstract": "Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease triggered by damage to the central nervous system (CNS). This CNS damage is caused by the attack of autoreactive T cells against the myelin sheath. Genetic and environmental factors contribute to the development of MS, and the condition causes serious disabilities and exerts substantial health burdens. Although various disease-modifying agents have been developed, they have critical limitations; hence, effective interventions are required. In this context, cell transplantation therapy using mesenchymal stem cells (MSCs), hematopoietic stem cells, neural precursors, neural stem cells, and induced pluripotent stem cells is considered a feasible alternative therapeutic approach. MSCs are adult stem cells that differentiate into multiple lineages and exert immunomodulatory, neuroprotective, and neuroregenerative effects. Therefore, MSCs are considered a promising treatment option for MS owing to their ease of isolation and low immunogenicity. This review summarizes the potential therapeutic benefits of the latest MSC-based approaches for MS treatment in animal models and humans. Furthermore, the review discusses the immunological role of MSCs and future directions for their applications.",
  "abstract_shown": true,
  "affiliations": [
    "College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University Incheon 21936 Republic of Korea"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jungeun An"
    },
    {
      "affs": [
        0
      ],
      "name": "Dongeun Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Ji Min Baek"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Jeong Park"
    },
    {
      "affs": [
        0
      ],
      "name": "Ye Won Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Hye Eum Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Kyung Hee Choi"
    },
    {
      "affs": [
        0
      ],
      "name": "Sung Jean Park"
    },
    {
      "affs": [
        0
      ],
      "name": "Hee-Sook Jun"
    },
    {
      "affs": [
        0
      ],
      "name": "Donghee Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Ji Woong Choi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ad7s2vvys6tvv.bib",
  "cited_by": 0,
  "doi": "10.4062/biomolther.2026.141",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725006/",
  "id": "ad7s2vvys6tvv",
  "issns": [
    "1976-9148",
    "2005-4483"
  ],
  "landing_url": "https://doi.org/10.4062/biomolther.2026.141",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2734|Multiple Sclerosis Research Studies"
    ]
  ],
  "openalex": "W7224186022",
  "pdf_url": null,
  "pmcid": "PMC13725006",
  "pmid": "42952209",
  "published": "2026-11-01",
  "publisher": "Korean Society of Applied Pharmacology",
  "ris": "https://research.draconitic.com/paper/ad7s2vvys6tvv.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:29Z",
      "native_id": "PMC13725006",
      "source": "pmc",
      "url": "https://doi.org/10.4062/biomolther.2026.141"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Multiple Sclerosis Research Studies",
      "subfield": "general"
    }
  ],
  "title": "Mesenchymal Stem Cell Therapy for Multiple Sclerosis: Harnessing Immunological Properties",
  "title_text": "Mesenchymal Stem Cell Therapy for Multiple Sclerosis: Harnessing Immunological Properties",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:22Z",
  "url": "https://research.draconitic.com/paper/ad7s2vvys6tvv",
  "venue": "Biomolecules & Therapeutics",
  "versions": []
}