{
  "abstract": "Proximity is a fundamental prerequisite for a diverse range of biological processes. Chemically induced proximity strategies exploit this principle to achieve the controllable modulation of targets of interest through programmable biomolecular interactions. By rewiring biological interactions, induced-proximity technologies can regulate protein stability, activity, localization, transcription, and signaling. Recent advances have greatly expanded the repertoire of recruitable effector proteins, enabling the manipulation of challenging targets previously considered intractable. In this review, we summarize the conceptual evolution and mechanistic diversity of induced-proximity technologies, highlighting platforms for targeted protein degradation, stabilization, post-translational modification editing, protein relocalization, and transcriptional control.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.",
    "Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.",
    "Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, United States.",
    "Center for Human Immunobiology, Northwestern University, Chicago, Illinois 60611, United States.",
    "International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaokang Jin",
      "orcid": "0009-0005-7011-8199"
    },
    {
      "affs": [
        0
      ],
      "name": "Chen Zhou"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Xiaoyu Zhang",
      "orcid": "0000-0002-0951-9664"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/adg32qtdd1xs0.bib",
  "cited_by": 0,
  "doi": "10.1021/acsbiomedchemau.6c00121",
  "fulltext_url": "https://europepmc.org/articles/PMC13692737",
  "id": "adg32qtdd1xs0",
  "issns": [
    "2694-2437"
  ],
  "landing_url": "https://europepmc.org/article/MED/42921024",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Protein Degradation and Inhibitors"
    ]
  ],
  "openalex": "W7204792701",
  "pdf_url": "https://europepmc.org/articles/PMC13692737?pdf=render",
  "pmcid": "PMC13692737",
  "pmid": "42921024",
  "published": "2026-08-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/adg32qtdd1xs0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42921024",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42921024"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Protein Degradation and Inhibitors",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Chemically Induced Proximity in Biological Modulation.",
  "title_text": "Chemically Induced Proximity in Biological Modulation.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/adg32qtdd1xs0",
  "venue": "ACS bio & med chem Au",
  "versions": []
}