{
  "abstract": "Background:: Critically ill obstetric patients in intensive care units (ICUs) present unique challenges, and maternal mortality remains a major concern, particularly in low- and middle-income countries. The Sequential Organ Failure Assessment (SOFA) score, though widely used in general ICUs, has not been adequately studied for its organ-specific discriminatory power in predicting maternal mortality. This study aimed to evaluate the prognostic accuracy of individual organ SOFA sub-scores to improve risk stratification in obstetric critical care.\n\nMethods:: This prospective observational study was conducted over one year in the obstetric ICU of a tertiary center in Northern India. A total of 125 obstetric patients (pregnant or within 42 days postpartum) were enrolled. SOFA sub-scores for respiratory, cardiovascular, hepatic, renal, coagulation, and neurological systems were calculated on admission and throughout ICU stay. Patients were classified into survivors and non-survivors. Associations between individual organ dysfunction and maternal mortality were assessed. Discriminatory accuracy of organ-specific SOFA scores was determined using receiver operating characteristic (ROC) curve analysis.\n\nResults:: Mortality increased proportionally with the number of dysfunctional organs (χ² =39.693; P < 0.001). Escalating organ-specific SOFA scores were significantly associated with maternal mortality. ROC analysis revealed that cardiovascular dysfunction had the highest predictive accuracy (area under the curve [AUC] =0.875), followed by hepatic (AUC = 0.808), respiratory (AUC = 0.804), hematological (AUC = 0.763), and renal (AUC = 0.757) dysfunction.\n\nConclusion:: Cardiovascular, hepatic, and respiratory SOFA sub-scores provide strong discriminatory power for predicting maternal mortality in Obstetric ICU patients. Incorporating organ-specific SOFA assessments may enhance early risk stratification and guide life-saving interventions in resource-limited settings.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynaecology, King George’s Medical University, Lucknow, Uttar Pradesh, India",
    "Department of Obstetrics and Gynaecology, Rani Durgavati Medical College, Banda, Uttar Pradesh, India",
    "Department of Critical Care, King George’s Medical University, Lucknow, Uttar Pradesh, India"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Monica Agrawal"
    },
    {
      "affs": [
        1
      ],
      "name": "Kathipri Nelia"
    },
    {
      "affs": [
        2
      ],
      "name": "Armin Ahmed"
    },
    {
      "affs": [
        0
      ],
      "name": "Sujata Deo"
    },
    {
      "affs": [
        0
      ],
      "name": "Shyam P. Jaiswar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/adny5cgk48b1f.bib",
  "cited_by": 0,
  "doi": "10.4103/jfmpc.jfmpc_2216_25",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722232/?tool=EBI",
  "id": "adny5cgk48b1f",
  "issns": [
    "2249-4863",
    "2278-7135"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13722232",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7220858662",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722232/pdf/?tool=EBI",
  "pmcid": "PMC13722232",
  "pmid": "42965191",
  "published": "2026-07-01",
  "publisher": "Wolters Kluwer -- Medknow Publications",
  "ris": "https://research.draconitic.com/paper/adny5cgk48b1f.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:45Z",
      "native_id": "PMC:PMC13722232",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13722232"
    },
    {
      "first_seen": "2026-11-03T12:22:47Z",
      "native_id": "PMC13722232",
      "source": "pmc",
      "url": "https://doi.org/10.4103/jfmpc.jfmpc_2216_25"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Discriminatory power of organ-specific Sequential Organ Failure Assessment (SOFA) scores: Predictors of maternal mortality in obstetric intensive care units (ICU)",
  "title_text": "Discriminatory power of organ-specific Sequential Organ Failure Assessment (SOFA) scores: Predictors of maternal mortality in obstetric intensive care units (ICU)",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:47Z",
  "url": "https://research.draconitic.com/paper/adny5cgk48b1f",
  "venue": "Journal of family medicine and primary care",
  "versions": []
}