{
  "abstract": "Background: Full-thickness macular hole (FTMH) is a vitreoretinal condition affecting the foveal center that causes central vision loss and metamorphopsia. Despite high surgical success in achieving closure, functional visual recovery remains unpredictable. Identifying reliable optical coherence tomography (OCT) biomarkers that predict postoperative outcomes could improve patient counselling and surgical decision-making. Objective: To systematically evaluate the predictive value of baseline structural OCT biomarkers for visual acuity (VA) outcomes at 3, 6, 12, and 24 months following FTMH surgery. Methods: We will search PubMed, EMBASE, Cochrane Library, and Web of Science databases from inception for studies evaluating baseline OCT parameters as predictors of postoperative VA outcomes following FTMH surgery, with minimum follow-up of 3 months. Data will be synthesized using random-effects meta-analyses. The certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Conclusions: This systematic review will synthesize current evidence on OCT biomarkers’ predictive value for FTMH surgical outcomes. The findings will clarify their clinical utility and may inform individualized prognostic counselling and surgical decision-making, including which patients are most likely to benefit from surgery and which surgical techniques may be most effective given specific OCT profiles.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada",
    "Thomas Kevill Advanced Vitreoretinal Imaging (AVI) Lab, St Joseph’s Healthcare, Hamilton, ON, Canada",
    "Department of Surgery, McMaster University, Hamilton, ON, Canada",
    "Department of Anesthesia, McMaster University, Hamilton, ON, Canada",
    "School of Public Health, University of Alberta, Edmonton, Alberta, Canada",
    "Retina Consultants of Texas, Houston, Texas, United States of America",
    "Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States of America",
    "Beijing Visual Science and Translational Eye Research Institute, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China",
    "Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore",
    "Tsinghua Medicine, Tsinghua University, Beijing, China",
    "School of Biomedical Engineering, Tsinghua Medicine, Tsinghua University, Beijing, China"
  ],
  "article_type": "Study Protocol",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sahar Khademioore"
    },
    {
      "affs": [
        1
      ],
      "name": "João Pedro Lima"
    },
    {
      "affs": [
        2
      ],
      "name": "Dena Zeraatkar"
    },
    {
      "affs": [
        3
      ],
      "name": "Sadia Mahmood"
    },
    {
      "affs": [
        4
      ],
      "name": "Sara Khademioureh"
    },
    {
      "affs": [
        5
      ],
      "name": "Charles C. Wykoff"
    },
    {
      "affs": [
        6
      ],
      "name": "Peter K. Kaiser"
    },
    {
      "affs": [
        7
      ],
      "name": "Tien-Yin Wong"
    },
    {
      "affs": [
        8
      ],
      "name": "Jiayuan Cheng"
    },
    {
      "affs": [
        9
      ],
      "name": "Mengda Li"
    },
    {
      "affs": [
        10
      ],
      "name": "Varun Chaudhary"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/adwt53nb3thn2.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0359108",
  "fulltext_url": null,
  "id": "adwt53nb3thn2",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0359108",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Retinal and Macular Surgery"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Biomarkers"
    ],
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Cognitive science/Cognitive psychology/Perception/Sensory perception/Vision"
    ],
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Cognitive science/Cognitive psychology/Perception/Sensory perception/Vision/Visual acuity"
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      "/Biology and life sciences/Neuroscience/Sensory perception/Vision"
    ],
    [
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      "/Biology and life sciences/Neuroscience/Sensory perception/Vision/Visual acuity"
    ],
    [
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      "/Biology and life sciences/Psychology/Cognitive psychology/Perception/Sensory perception/Vision"
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      "/Biology and life sciences/Psychology/Cognitive psychology/Perception/Sensory perception/Vision/Visual acuity"
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      "/Medicine and health sciences/Radiology and imaging/Diagnostic radiology/Tomography"
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      "/Medicine and health sciences/Surgical and invasive medical procedures"
    ],
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      "/Medicine and health sciences/Surgical and invasive medical procedures/Ophthalmic procedures/Macular hole surgery"
    ],
    [
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      "/Medicine and health sciences/Surgical and invasive medical procedures/Ophthalmic procedures/Vitreoretinal surgery"
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      "/Research and analysis methods/Imaging techniques/Diagnostic radiology/Tomography"
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      "/Social sciences/Psychology/Cognitive psychology/Perception/Sensory perception/Vision"
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      "/Social sciences/Psychology/Cognitive psychology/Perception/Sensory perception/Vision/Visual acuity"
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  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0359108&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/adwt53nb3thn2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:37Z",
      "native_id": "10.1371/journal.pone.0359108",
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      "url": "https://doi.org/10.1371/journal.pone.0359108"
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  "subjects": [
    {
      "field": "biology",
      "origin": "plos:neuroscience",
      "subfield": "neuroscience"
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    {
      "field": "medicine",
      "origin": "plos:diagnostic radiology",
      "subfield": "imaging"
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    {
      "field": "medicine",
      "origin": "plos:surgical and invasive medical procedures",
      "subfield": "surgery"
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  "title": "OphthoEvidence report: Baseline structural optical coherence tomography biomarkers as predictors of visual outcomes following full-thickness macular hole surgery: A systematic review and meta-analysis protocol",
  "title_text": "OphthoEvidence report: Baseline structural optical coherence tomography biomarkers as predictors of visual outcomes following full-thickness macular hole surgery: A systematic review and meta-analysis protocol",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:37Z",
  "url": "https://research.draconitic.com/paper/adwt53nb3thn2",
  "venue": "PLOS One",
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}