{
  "abstract": "Accurate assessment of lymph node metastasis (LNM) is important for staging and treatment planning in older patients with non-small cell lung cancer (NSCLC), but invasive nodal evaluation may be limited by comorbidities and reduced physiologic reserve. We aimed to characterize the burden of LNM and develop a prediction model for patients aged ≥70 years with NSCLC. Patients aged ≥70 years with histologically confirmed NSCLC were identified from the Surveillance, Epidemiology, and End Results database and randomly split into training (70%) and internal validation (30%) cohorts. Independent predictors of LNM were identified using multivariable logistic regression, and a nomogram was constructed. Model performance was assessed by the area under the receiver operating characteristic curve (AUC), calibration, and decision curve analysis. A total of 59,128 patients were included. In 2022, LNM was identified in 48.2% of patients. Age, sex, race, histologic subtype, tumor laterality, tumor location, tumor grade, T stage, M stage, tumor size, and bone, lung, and liver metastases were independent predictors of LNM. The model showed acceptable discrimination, with AUCs of 0.78 and 0.79 in the training and internal validation cohorts, respectively. LNM was associated with higher lung cancer-specific mortality and lower non-lung cancer mortality. We developed a practical, noninvasive prediction model for LNM in older patients with NSCLC, which may support individualized risk stratification and clinical management.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory Diseases, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hongquan Xing",
      "orcid": "0000-0002-0027-2773"
    },
    {
      "affs": [
        0
      ],
      "name": "Weichang Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Sunying Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoqun Ye"
    },
    {
      "affs": [
        0
      ],
      "name": "Guofeng Zhu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/adzehnrh2ccgv.bib",
  "cited_by": 0,
  "doi": "10.21037/tcr-2026-1926",
  "fulltext_url": "https://europepmc.org/articles/PMC13743211",
  "id": "adzehnrh2ccgv",
  "issns": [
    "2218-676X",
    "2219-6803"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997900",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Lung Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7222637230",
  "pdf_url": "https://europepmc.org/articles/PMC13743211?pdf=render",
  "pmcid": "PMC13743211",
  "pmid": "42997900",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/adzehnrh2ccgv.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42997900",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997900"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Lung Cancer Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "A population-based prediction model for lymph node metastasis in patients aged ≥70 years with non-small cell lung cancer.",
  "title_text": "A population-based prediction model for lymph node metastasis in patients aged ≥70 years with non-small cell lung cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/adzehnrh2ccgv",
  "venue": "Translational cancer research",
  "versions": []
}