{
  "abstract": "BackgroundThe systemic coagulation inflammation (SCI) index has been investigated as a prognostic marker in several diseases. The aim of this study was to investigate the association of SCI with mortality in patients undergoing peritoneal dialysis (PD).MethodsA total of 324 incident PD patients who initiated treatment between January 2011 and December 2020 were retrospectively analyzed. Patients were stratified using the previously selected outcome-specific SCI cutoffs. Mortality associations were assessed using Cox regression and, for cardiovascular disease (CVD) mortality, competing-risk methods.ResultsPatients were stratified with three groups based on the optimal cutoff value of SCI index. In the primary model (Model 2), lower SCI was associated with increased all-cause mortality (hazard ratio [HR], 9.32; 95% CI, 4.55–19.08, P < 0.001). For CVD mortality, the corresponding HR was 7.03 (95% CI, 3.83–12.92, P < 0.001). SCI areas under the receiver operating characteristic (ROC) curve were 0.681 and 0.688 for all-cause and CVD mortality, respectively. Significant differences in overall survival were observed in older and hypertension population.ConclusionsLower SCI index was associated with higher mortality in this PD cohort. Discrimination was modest, and the data-derived cutoffs require independent validation before clinical use.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nephrology, Jiangyin People’s Hospital Affiliated to Nantong University, Jiangyin, China",
    "Department of Nephrology, Affiliated Hospital of Yangzhou University, Yangzhou First People’s Hospital, Yangzhou, China",
    "Department of Nephrology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China",
    "Department of Nephrology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China",
    "Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich, Germany"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tianying Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xi Hua"
    },
    {
      "affs": [
        2
      ],
      "name": "Dong Sun"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiangcheng Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenkai Xia"
    },
    {
      "affs": [
        4
      ],
      "name": "Wenkai Xia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ae70c8bzs9q7n.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.2005361",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fmed.2026.2005361/full",
  "id": "ae70c8bzs9q7n",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://doi.org/10.3389/fmed.2026.2005361",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2727|Dialysis and Renal Disease Management"
    ]
  ],
  "openalex": "W7223648672",
  "pdf_url": "https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.2005361/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/ae70c8bzs9q7n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:18Z",
      "native_id": "394ddc1c55f34ace9f0d427a4b0d9ab3",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fmed.2026.2005361"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Dialysis and Renal Disease Management",
      "subfield": "general"
    }
  ],
  "title": "Systemic coagulation inflammation index and risk of mortality in peritoneal dialysis patients: a multicenter cohort study",
  "title_text": "Systemic coagulation inflammation index and risk of mortality in peritoneal dialysis patients: a multicenter cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:18Z",
  "url": "https://research.draconitic.com/paper/ae70c8bzs9q7n",
  "venue": "Frontiers in Medicine",
  "versions": []
}