{
  "abstract": "Post–COVID-19 pandemic Mycoplasma pneumoniae resurgences have occurred globally and have been particularly severe in Taiwan. We conducted a multicenter study to assess M. pneumoniae trends in children. Compared with the 2019 peak, 2024 data revealed a doubling of incidence (546/100,000 population), a 2.2-fold increase in intensive care unit admissions (10.9/100,000 population), and a 13.7-fold surge in central nervous system complications (6.1/100,000 population). In a 2023–2024 prospective cohort (n = 226), intensive care unit admission risk factors were neutrophils >7,000/μL (adjusted odds ratio [aOR] 6.2 [95% CI 1.3–29.9]), platelets >400 × 103/μL (aOR 12.5 [95% CI 2.7–57.9]), pleural effusion (aOR 9.7 [95% CI 1.6–58.1]), and central nervous system involvement (aOR 27.9 [95% CI 4.1–188.3]). Phylogenetic analysis of 698 genomes demonstrated that 4 emerging subclades replaced pre–COVID-19 lineages by mid-2024; 1 subclade was associated with severe outcomes, highlighting evolving resistant, neurotropic lineages and calling for enhanced surveillance.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Yu-Chia Hsieh"
    },
    {
      "name": "Chen-Ching Lin"
    },
    {
      "name": "Jia-Wen Wu"
    },
    {
      "name": "Yi-Hsuan Liu"
    },
    {
      "name": "Yi-Jiun Pan"
    },
    {
      "name": "Tzu-Ya Lo"
    },
    {
      "name": "Shian-Sen Shie"
    },
    {
      "name": "Huey-Ling You"
    },
    {
      "name": "Chong-Wei Huang"
    },
    {
      "name": "Yi-Chuan Huang"
    },
    {
      "name": "Tzu-Ching Huang"
    },
    {
      "name": "Yu-Xin She"
    },
    {
      "name": "Yin-Cheng Chen"
    },
    {
      "name": "Shiao-Wen Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ae871g0ewhaa7.bib",
  "cited_by": 0,
  "doi": "10.3201/eid3211.260439",
  "fulltext_url": "https://wwwnc.cdc.gov/eid/article/32/11/26-0439_article",
  "id": "ae871g0ewhaa7",
  "issns": [
    "1080-6040",
    "1080-6059"
  ],
  "landing_url": "https://doi.org/10.3201/eid3211.260439",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "lcc",
      "RC109-216"
    ],
    [
      "openalex",
      "2404|Microbial infections and disease research"
    ]
  ],
  "openalex": "W7221746776",
  "pdf_url": null,
  "pmcid": "PMC13715894",
  "pmid": "42909847",
  "published": "2026-10-30",
  "publisher": "Centers for Disease Control and Prevention",
  "ris": "https://research.draconitic.com/paper/ae871g0ewhaa7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:09Z",
      "native_id": "a287aa3654c2478286a1342085340365",
      "source": "doaj",
      "url": "https://doi.org/10.3201/eid3211.260439"
    },
    {
      "first_seen": "2026-11-01T12:23:05Z",
      "native_id": "PMC13715894",
      "source": "pmc",
      "url": "https://doi.org/10.3201/eid3211.260439"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2404|Microbial infections and disease research",
      "subfield": "microbiology"
    }
  ],
  "title": "Emergence of Novel Macrolide-Resistant Mycoplasma pneumoniae Sequence Type 3 Subclades in Children after COVID-19 Pandemic, Taiwan",
  "title_text": "Emergence of Novel Macrolide-Resistant Mycoplasma pneumoniae Sequence Type 3 Subclades in Children after COVID-19 Pandemic, Taiwan",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:19Z",
  "url": "https://research.draconitic.com/paper/ae871g0ewhaa7",
  "venue": "Emerging Infectious Diseases",
  "versions": []
}