{
  "abstract": "BRD7 serves as a critical tumor suppressor, yet it is frequently inactivated via ubiquitination‐mediated proteasomal degradation, facilitating tumor progression and metastasis. Although stabilizing or activating BRD7 represents a promising therapeutic strategy, pharmacological agents to achieve this remain limited. Here, we aimed to develop a peptide‐based approach to enhance BRD7 protein stability. We first mapped the TRIM28‐BRD7 interaction to the 299–349 aa region within the Coiled‐coil domain of TRIM28. Based on this interface, we designed two α‐helical peptides, TAB12 and TAB14, that mimic the key structural features. Mechanistically, TAB12 exhibits strong binding affinity toward BRD7 protein and competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking TRIM28‐mediated BRD7 ubiquitination and stabilizing endogenous BRD7. In vitro functional assays demonstrated that TAB12 markedly inhibits tumor cell proliferation, migration, and invasion, induces cell apoptosis, and presents low cytotoxicity toward normal cells. Subsequent rescue experiments confirmed that BRD7 knockdown substantially abrogates the anti‐tumor effects of TAB12, verifying that TAB12's function depends on stabilizing BRD7. Furthermore, in vivo animal models validated that TAB12 significantly suppresses tumor growth with a favorable safety profile. Therefore, this study identifies a novel peptide agent that exerts broad anti‐tumor effects by stabilizing BRD7, offering a feasible strategy for restoring tumor suppressor function.",
  "abstract_shown": true,
  "affiliations": [
    "NHC Key Laboratory of Carcinogenesis Hunan Key Laboratory of Oncotarget Gene Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China",
    "Cancer Research Institute and School of Basic Medical Sciences Central South University Changsha China",
    "The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Central South University Changsha China",
    "Xiangya School of Medicine Central South University Changsha China",
    "Department of Blood Transfusion The Third Xiangya Hospital Central South University Changsha Hunan China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Qingqing Wei",
      "orcid": "0009-0009-4902-009X"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Changning Xue"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Mengna Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jianxia Wei"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Lemei Zheng"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shipeng Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Yijie Wang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Yumei Duan"
    },
    {
      "affs": [
        4
      ],
      "name": "Yanwei Luo",
      "orcid": "0000-0003-0653-8007"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Wei Xiong",
      "orcid": "0000-0003-1635-8173"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ming Zhou",
      "orcid": "0000-0003-4938-5397"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aebak1mxh0bqh.bib",
  "cited_by": 0,
  "doi": "10.1002/advs.76974",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13440194/",
  "id": "aebak1mxh0bqh",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://doi.org/10.1002/advs.76974",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1312|Protein Degradation and Inhibitors"
    ]
  ],
  "openalex": "W7172535860",
  "pdf_url": null,
  "pmcid": "PMC13440194",
  "pmid": "42554600",
  "published": "2026-08-05",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/aebak1mxh0bqh.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:41Z",
      "native_id": "PMC13440194",
      "source": "pmc",
      "url": "https://doi.org/10.1002/advs.76974"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Protein Degradation and Inhibitors",
      "subfield": "molecular-biology"
    }
  ],
  "title": "TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers",
  "title_text": "TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:48Z",
  "url": "https://research.draconitic.com/paper/aebak1mxh0bqh",
  "venue": "Advanced Science",
  "versions": []
}