{
  "abstract": "Degenerative lumbosacral stenosis (DLSS) causes progressive nerve root compression, leading to cauda equina syndrome (CES) and painful gait impairments in dogs. Epidural co-administration of autologous conditioned serum (ACS) and glucocorticoids (GC) is used as a conservative intervention, but objective outcome data remain lacking. This retrospective exploratory study evaluated whether an inertial measurement unit (IMU)-based kinematic system (LupoGait) could detect gait changes following a single epidural injection of ACS and triamcinolone acetonide in 44 dogs with CES. Nominal post-treatment changes were observed in several hindlimb parameters, including stance phase (HL +0.03, 95% CI 0.005–0.05, p = 0.018), maximum gyroscope amplitude (HL +0.32, 95% CI 0.02 to 0.69, p = 0.032), and variance of the differentiated gyroscope signal (HL +0.10, 95% CI 0.01 to 0.23, p = 0.036). However, no evaluated outcomes remained statistically significant after correction for multiple comparisons. Given the uncontrolled retrospective design, these exploratory findings cannot establish therapeutic efficacy or isolate ACS-specific effects from GC administration. Nevertheless, this study demonstrates the feasibility of IMU-based kinematic analysis for objective longitudinal monitoring in dogs with CES and provides preliminary baseline data for prospective, controlled clinical trials.",
  "abstract_shown": true,
  "affiliations": [
    "orthoVET, Fasanenstrasse 13, Frenkendorf, CH-4402, Switzerland",
    "Cavia, Iwamoto 537132, Fuji, Shizuoka, 416-0901, Japan",
    "FHNW University of Applied Sciences Northwestern Switzerland - Campus Muttenz, Hofackerstrasse 30, 4132 Muttenz, Basel-Land, Switzerland",
    "Orthogen Veterinary GmbH, Ernst-Schneider-Platz 1, Düsseldorf, 40212, Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Patrick Blaettler Monnier"
    },
    {
      "affs": [
        1
      ],
      "name": "Indre Matsuzaki"
    },
    {
      "affs": [
        2
      ],
      "name": "Nico Gruetter"
    },
    {
      "affs": [
        3
      ],
      "name": "Julien Troillet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aekw7cqt43hrb.bib",
  "cited_by": 0,
  "doi": "10.1016/j.vas.2026.100911",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735292/",
  "id": "aekw7cqt43hrb",
  "issns": [
    "2451-943X"
  ],
  "landing_url": "https://doi.org/10.1016/j.vas.2026.100911",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "3404|Veterinary Orthopedics and Neurology"
    ]
  ],
  "openalex": "W7223004124",
  "pdf_url": null,
  "pmcid": "PMC13735292",
  "pmid": "42991106",
  "published": "2026-10-20",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/aekw7cqt43hrb.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:00Z",
      "native_id": "PMC13735292",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.vas.2026.100911"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "journal-openalex:F11",
      "subfield": "general"
    }
  ],
  "title": "Kinematic changes following concurrent epidural injection with autologous conditioned serum (ACS) and glucocorticoids in dogs with cauda equina syndrome",
  "title_text": "Kinematic changes following concurrent epidural injection with autologous conditioned serum (ACS) and glucocorticoids in dogs with cauda equina syndrome",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:00Z",
  "url": "https://research.draconitic.com/paper/aekw7cqt43hrb",
  "venue": "Veterinary and Animal Science",
  "versions": []
}