{
  "abstract": "Synaptic plasticity is the principal mechanism by which neural circuits compute and adapt. Presynaptic plasticity is traditionally regarded as a transient adaptation of the synaptic vesicle fusion and recycling machinery, whereas the role of structural remodeling of synaptic boutons remains unclear. Here, we demonstrate a mechanical coupling between presynaptic structural remodeling and synaptic efficacy. We find that dynamic presynaptic filopodia emerge during active synaptic transmission and deform synaptic boutons while forming transient contacts with postsynaptic structures, which we term neuronal kinapses. Filopodia formation is activity dependent and occurs in intact circuits and human brain. Mechanistically, filopodial growth induces convective in-plane membrane flow toward the filopodium, accelerating release site clearance, a process associated with sustained release probability during repeated synaptic vesicle fusion. As a result, filopodia formation favors an increase in synchronous over asynchronous neurotransmitter release. These results indicate that presynaptic structural remodeling can alter the spatial organization of neurotransmission and, through the membrane flow it generates, modulate its temporal precision.",
  "abstract_shown": true,
  "affiliations": [
    "Institute for Neuroscience and Cardiovascular Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh, Scotland, UK.",
    "Muir Maxwell Epilepsy Centre, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh, Scotland, UK.",
    "Simons Initiative for the Developing Brain, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh, Scotland, UK.",
    "Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.",
    "Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.",
    "Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neurophysiology, Charitéplatz 1, Berlin, Germany.",
    "The Roslin Institute 3D Volume Electron Microscopy Capability, Proteomics and Metabolomics Facility, The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, Scotland, UK.",
    "Johannes Gutenberg University Mainz, Institute of Developmental Biology and Neurobiology, AG Functional Neurobiology, Biocenter 1, Hanns-Dieter Hüsch Weg 15, Mainz, Germany.",
    "Kinases and Brain Development Lab, The Francis Crick Institute, London, UK."
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Akanksha Jain",
      "orcid": "0009-0007-9019-3051"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Rico Dong",
      "orcid": "0009-0000-1099-4246"
    },
    {
      "affs": [
        5
      ],
      "name": "Jana Kroll",
      "orcid": "0000-0003-4243-4088"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jack F. Webster",
      "orcid": "0000-0002-6188-4722"
    },
    {
      "affs": [
        6
      ],
      "name": "Jon Moss"
    },
    {
      "affs": [
        7
      ],
      "name": "Arthur Bikbaev"
    },
    {
      "affs": [
        8
      ],
      "name": "Sila K. Ultanir",
      "orcid": "0000-0001-5745-3957"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Alfredo Gonzalez-Sulser",
      "orcid": "0000-0003-3494-4029"
    },
    {
      "affs": [
        5
      ],
      "name": "Christian Rosenmund",
      "orcid": "0000-0002-3905-2444"
    },
    {
      "affs": [
        7
      ],
      "name": "Martin Heine",
      "orcid": "0000-0002-0886-3113"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Jian Liu",
      "orcid": "0000-0003-2935-0349"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Michael A. Cousin",
      "orcid": "0000-0002-1762-160X"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Daniela Ivanova",
      "orcid": "0000-0002-5378-0210"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aenxp0nkke8av.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aei2661",
  "fulltext_url": "https://europepmc.org/articles/PMC13715708",
  "id": "aenxp0nkke8av",
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      "heading",
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  "pdf_url": "https://europepmc.org/articles/PMC13715708?pdf=render",
  "pmcid": "PMC13715708",
  "pmid": "42950046",
  "published": "2026-10-28",
  "publisher": "American Association for the Advancement of Science (AAAS)",
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  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Cell Biology",
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    {
      "field": "biology",
      "origin": "heading:Neuroscience",
      "subfield": "neuroscience"
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  ],
  "title": "Presynaptic filopodia form kinapses and promote convective membrane flow to sustain synchronous neurotransmitter release",
  "title_text": "Presynaptic filopodia form kinapses and promote convective membrane flow to sustain synchronous neurotransmitter release",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:56Z",
  "url": "https://research.draconitic.com/paper/aenxp0nkke8av",
  "venue": "Science Advances",
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}