{
  "abstract": "Background:: Platelet-rich plasma (PRP) is used increasingly to treat knee osteoarthritis (OA). This study aimed to describe PRP use for knee OA and identify patient- and treatment-specific factors associated with clinical outcomes.\n\nHypothesis:: Patients with knee OA undergoing intra-articular PRP injections would demonstrate improvement in pain, function, and symptoms over time, with outcomes varying by patient and treatment characteristics.\n\nStudy Design:: Retrospective cohort study.\n\nLevel of Evidence:: Level 3.\n\nMethods:: A total of 743 patients with knee OA were treated with intra-articular PRP injections. Outcomes were assessed using the Numeric Rating Scale (NRS, 0-100, higher scores indicating greater pain) and the Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS-JR). Change in patient-reported outcome measure (PROM) scores from baseline and achievement of patient acceptable symptom state (PASS) were measured. Repeated-measures mixed models evaluated outcomes at baseline, 6 months, and 1 year using an all-response analysis (391 patients for Pain NRS; 400 for KOOS-JR).\n\nResults:: PRP injections were associated with improvement in pain, function, and symptom state. Pain NRS improved from 39.2 at baseline to 27.2 at 6 months and 22.4 at 1 year (both P < 0.001), while KOOS-JR improved from 60.7 to 68.5 and 69.1 (both P < 0.001), with similar findings in the complete-case cohort. When stratified by radiographic severity, patients with Kellgren-Lawrence (KL) grades 1 to 3 improved in both outcomes at 6 months and 1 year, while patients with KL grade 4 improved in Pain NRS at 1 year (P < 0.001) and KOOS-JR at 6 months (P = 0.01) and 1 year (P = 0.001). PASS achievement rates increased over time for both pain and function.\n\nConclusion:: Intra-articular PRP injections were associated with improvements in pain, function, and symptoms in patients with knee OA. Differences between complete-case and all-response analyses suggest that follow-up patterns may influence estimated treatment response.\n\nClinical Relevance:: These findings describe patient-reported outcomes after intra-articular PRP injection for knee OA. Because this study lacked a control group, findings should not be interpreted as evidence that PRP caused the observed improvements.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Primary Care Sports Medicine, Hospital for Special Surgery, New York, New York"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jonathan P. Coss"
    },
    {
      "affs": [
        0
      ],
      "name": "Kenar Z. Gelman",
      "orcid": "0009-0001-7657-6650"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryan Lingor",
      "orcid": "0000-0002-5653-0700"
    },
    {
      "affs": [
        0
      ],
      "name": "Kaylre Greaves"
    },
    {
      "affs": [
        0
      ],
      "name": "Courtney Melone"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael Parides"
    },
    {
      "affs": [
        0
      ],
      "name": "Brian C. Halpern"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aenxzvwadc3bh.bib",
  "cited_by": 0,
  "doi": "10.1177/19417381261496039",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710467/",
  "id": "aenxzvwadc3bh",
  "issns": [
    "1941-7381",
    "1941-0921"
  ],
  "landing_url": "https://doi.org/10.1177/19417381261496039",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2748|Periodontal Regeneration and Treatments"
    ]
  ],
  "openalex": "W7223658827",
  "pdf_url": null,
  "pmcid": "PMC13710467",
  "pmid": "42932248",
  "published": "2026-10-26",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/aenxzvwadc3bh.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:26Z",
      "native_id": "PMC13710467",
      "source": "pmc",
      "url": "https://doi.org/10.1177/19417381261496039"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2748|Periodontal Regeneration and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Platelet-Rich Plasma for Knee Osteoarthritis and Patient-Reported Outcomes: A Large Retrospective Analysis",
  "title_text": "Platelet-Rich Plasma for Knee Osteoarthritis and Patient-Reported Outcomes: A Large Retrospective Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:26Z",
  "url": "https://research.draconitic.com/paper/aenxzvwadc3bh",
  "venue": "Sports Health",
  "versions": []
}