{
  "abstract": "Purpose\n\nTo overcome dose-limiting toxicity and paclitaxel (PTX) resistance in triple-negative breast cancer (TNBC) therapy, as well as the asynchronous in vivo biodistribution of PTX and psoralen (PSO) combination regimens, we developed a highly biocompatible, magnetically targeted nano-co-delivery system.Methods\n\nPaclitaxel/psoralen-loaded magnetic composite nanoparticles (P/P-TCNs) were fabricated via nanoprecipitation. The nanocarriers comprise a poly(lactic-co-glycolic acid) (PLGA) core co-encapsulating both therapeutic agents and superparamagnetic iron oxide nanoparticles (SPIONs), shielded by a stabilizing outer phospholipid layer.Results\n\nPhysiochemically, P/P-TCNs exhibited uniform nanoscale dimensions, a negative surface charge, robust superparamagnetism, and synchronized drug release profiles. In vitro, P/P-TCNs significantly enhanced intracellular drug accumulation in 4T1 murine breast cancer cells, inducing profound G2/M cell cycle arrest and augmented apoptotic response. In vivo live imaging of tumor-bearing mice revealed that under an external magnetic field, P/P-TCNs selectively and efficiently accumulated at the tumor site via tail vein injection. This magnetically guided co-delivery achieved a potent tumor inhibition rate of >85%, significantly outperforming both the free drug combination and non-targeted nanoparticle controls. Furthermore, the nanoplatform demonstrated excellent hemocompatibility (<5% hemolysis) and negligible systemic toxicity in major organs.Conclusion\n\nP/P-TCNs facilitate the synchronized, safe, and highly efficient co-delivery of PTX and PSO. By maximizing nanocarrier‑facilitated combinatorial anti-TNBC efficacy while minimizing off-target toxicity, this biocompatible magnetic nanoplatform represents a promising translational strategy for the clinical management of refractory TNBC.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, People's Republic of China.",
    "International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, People's Republic of China.",
    "Guangdong Key Laboratory of Traditional Chinese Medicine Informatization, Jinan University, Guangzhou, People's Republic of China.",
    "International Science and Technology Cooperation Base of Guangdong Province, Jinan University, Guangzhou, People's Republic of China.",
    "School of Pharmacy, Jinan University, Guangzhou, People's Republic of China.",
    "School of Traditional Chinese Medicine, Jinan University, Guangzhou, People's Republic of China.",
    "Department of Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China.",
    "College of Pharmacy, University of Sargodha, Sargodha, Pakistan.",
    "Department of Oncology and Hematology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Manling Du",
      "orcid": "0009-0004-9388-1456"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        5
      ],
      "name": "Fengjie Liu"
    },
    {
      "affs": [
        6
      ],
      "name": "Panpan Wang"
    },
    {
      "affs": [
        7
      ],
      "name": "Mulazim Hussain Asim",
      "orcid": "0000-0003-1910-9615"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Qian Liu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Qianwen Li"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Mengjie Xie"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Kewei Zhang"
    },
    {
      "affs": [
        8
      ],
      "name": "Zhenjiang Yang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Yu Cai",
      "orcid": "0000-0002-8532-7816"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aerdsqfq48bhp.bib",
  "cited_by": 0,
  "doi": "10.2147/ijn.s641922",
  "fulltext_url": "https://europepmc.org/articles/PMC13682521",
  "id": "aerdsqfq48bhp",
  "issns": [
    "1176-9114",
    "1178-2013"
  ],
  "landing_url": "https://europepmc.org/article/MED/42904218",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7222209582",
  "pdf_url": "https://europepmc.org/articles/PMC13682521?pdf=render",
  "pmcid": "PMC13682521",
  "pmid": "42904218",
  "published": "2026-10-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aerdsqfq48bhp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42904218",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42904218"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Combination Therapeutic Effect of Psoralen and Paclitaxel-Loaded Superparamagnetic Iron Oxide Nanoparticles for the Treatment of Triple-Negative Breast Cancer.",
  "title_text": "Combination Therapeutic Effect of Psoralen and Paclitaxel-Loaded Superparamagnetic Iron Oxide Nanoparticles for the Treatment of Triple-Negative Breast Cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/aerdsqfq48bhp",
  "venue": "International journal of nanomedicine",
  "versions": []
}