{
  "abstract": "Objectives: This study aimed to assess the prognostic value of six-minute walk distance (6MWD) in stable HeartMate 3 (HM3) recipients.\n\nMethods: Data from patients with available 6MWD at 6 months post-implant were obtained from the prospective, multicentre ELEVATE registry. Overall survival and adverse event rates were analysed using Cox regression models adjusted for age and sex, with 6MWD as a continuous predictor, and stratified by median distance (350 m).\n\nResults: Six-minute walk distance at 6 months was available in 194 HM3 recipients. Patients walking < median were older (57 vs 52 years, P = .002), had more comorbidities, and reported lower quality of life. Six-minute walk distance correlated positively with haemoglobin (r = 0.20, P = .006) and EuroQoL-5 Dimensions visual analogue scale (EQ-5D VAS) (r = 0.23, P = .004), and inversely with New York Heart Association (NYHA) class (r = –0.47, P < .0001). Kaplan-Meier analyses of patients walking < or ≥ 350 m showed no significant differences in survival (log-rank P = .379), right heart failure (HF) (P = .334), or rehospitalization (P = .243), while survival free from haemocompatibility-related adverse events differed significantly, although marginally (P = .049). Cox models confirmed that 6MWD had no independent prognostic value for mortality (HR 0.98, 95% CI, 0.96-1.01, P = .26) or secondary outcomes. However, patients with < median 6MWD experienced higher rates of major bleeding (Incidence rate ratio (IRR) 2.88, P < .001), major infection (IRR 2.14, P < .0001), and renal dysfunction (IRR 4.78, P = .033).\n\nConclusions: Shorter 6MWD 6 months after HM3 implantation was associated with a higher risk of some adverse events (AEs) but was not prognostic for mortality, HF recurrence, or rehospitalization risk. The prognostic value of 6MWD in HF patients without circulatory support cannot be extrapolated to patients treated with current left ventricular assist devices (LVADs).\n\nClinical trial registration number: ClinicalTrials.gov Identifier: NCT02497950.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "William Herrik Nielsen",
      "orcid": "0000-0003-2783-6409"
    },
    {
      "name": "Finn Gustafsson",
      "orcid": "0000-0003-2144-341X"
    },
    {
      "name": "Steven Shaw",
      "orcid": "0000-0002-4939-3728"
    },
    {
      "name": "Jens Garbade",
      "orcid": "0000-0002-9239-2341"
    },
    {
      "name": "Michiel Morshuis",
      "orcid": "0000-0002-6178-5791"
    },
    {
      "name": "Daniel Zimpfer",
      "orcid": "0000-0002-2185-4895"
    },
    {
      "name": "Jacob Lavee",
      "orcid": "0000-0002-3641-1114"
    },
    {
      "name": "Laura Walker",
      "orcid": "0009-0004-1806-1765"
    },
    {
      "name": "Carlye Kraemer",
      "orcid": "0009-0009-6787-4283"
    },
    {
      "name": "Carlo Gazzola",
      "orcid": "0000-0001-6618-7101"
    },
    {
      "name": "Diyar Saeed",
      "orcid": "0000-0001-7449-9455"
    },
    {
      "name": "ELEVATE Registry Investigators"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/af4dpmecfbtq7.bib",
  "cited_by": 0,
  "doi": "10.1093/icvts/ivag241",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730604/",
  "id": "af4dpmecfbtq7",
  "issns": [
    "2753-670X"
  ],
  "landing_url": "https://doi.org/10.1093/icvts/ivag241",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00920"
    ],
    [
      "heading",
      "Eacts/103"
    ],
    [
      "heading",
      "Eacts/118"
    ],
    [
      "heading",
      "Eacts/173"
    ],
    [
      "heading",
      "Heart Failure"
    ],
    [
      "heading",
      "Original article"
    ],
    [
      "openalex",
      "2705|Mechanical Circulatory Support Devices"
    ]
  ],
  "openalex": "W7212242129",
  "pdf_url": null,
  "pmcid": "PMC13730604",
  "pmid": "42726105",
  "published": "2026-09-11",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/af4dpmecfbtq7.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:23:07Z",
      "native_id": "PMC13730604",
      "source": "pmc",
      "url": "https://doi.org/10.1093/icvts/ivag241"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Mechanical Circulatory Support Devices",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Six-Minute Walk Distance and Long-Term Outcomes in Contemporary Left Ventricular Assist Device Recipients: The ELEVATE Registry",
  "title_text": "Six-Minute Walk Distance and Long-Term Outcomes in Contemporary Left Ventricular Assist Device Recipients: The ELEVATE Registry",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:23:07Z",
  "url": "https://research.draconitic.com/paper/af4dpmecfbtq7",
  "venue": "Interdisciplinary Cardiovascular and Thoracic Surgery",
  "versions": []
}