{
  "abstract": "Granulocytic myeloid-derived suppressor cells (G-MDSCs) are immunoregulatory cells of the neutrophil lineage. Here, we show that immunoregulation by G-MDSCs is imprinted by the joint tissue microenvironment in patients with axial spondyloarthritis and in animal models of inflammatory arthritis. We demonstrate that the suppressive function of G-MDSCs is significantly enhanced in the joint tissue, but not in the circulation. Analysis of public single-cell RNA sequencing datasets was consistent with Cd200r1 high Hmgb2 ⁺ precursors differentiating into G-MDSCs following interaction with Cd200 ⁺ fibroblasts. In hTNFtg/ Il23mc mice, treatment with a CD200R1 agonist promoted an immunoregulatory signature associated with PD-L1 expression, whereas CD200 blockade reversed the phenotype. Following adoptive transfer of G-MDSC precursor cells into arthritic mice, administration of a CD200-blocking antibody impaired the differentiation of PD-L1 ⁺ G-MDSCs and exacerbated disease severity. These findings reveal a tissue-intrinsic program that facilitates resolution of inflammation through fibroblast-myeloid crosstalk that enhances G-MDSC function.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 25,
  "authors": [
    {
      "name": "Mario R. Angeli",
      "orcid": "0000-0002-2911-4269"
    },
    {
      "name": "Christian Schütz",
      "orcid": "0000-0002-2361-2785"
    },
    {
      "name": "Hashem Schmidt"
    },
    {
      "name": "Richard Demmler",
      "orcid": "0009-0004-3476-2481"
    },
    {
      "name": "Jiyang Chang"
    },
    {
      "name": "Hannah Labinsky"
    },
    {
      "name": "Maria Gabriella Raimondo",
      "orcid": "0000-0003-2020-6711"
    },
    {
      "name": "Brikena Lalazi"
    },
    {
      "name": "Katerina Stergioula"
    },
    {
      "name": "Kaiyue Huang"
    },
    {
      "name": "Vladyslav Fedorchenko"
    },
    {
      "name": "Mohan Li"
    },
    {
      "name": "Zoltán Winter",
      "orcid": "0000-0003-4119-9637"
    },
    {
      "name": "Styliani Tsiami"
    },
    {
      "name": "Arnd Lienert"
    },
    {
      "name": "Sebastian Rütten"
    },
    {
      "name": "Stefanie Weber"
    },
    {
      "name": "Markus Luber",
      "orcid": "0000-0003-1895-5481"
    },
    {
      "name": "Tobias Bäuerle"
    },
    {
      "name": "Reza Bahrami",
      "orcid": "0009-0005-6299-5546"
    },
    {
      "name": "Heinrich Boehm"
    },
    {
      "name": "Georg Schett",
      "orcid": "0000-0001-8740-9615"
    },
    {
      "name": "Simon Rauber",
      "orcid": "0000-0001-8306-9334"
    },
    {
      "name": "Xenofon Baraliakos"
    },
    {
      "name": "Andreas Ramming",
      "orcid": "0000-0002-7003-501X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/afr9kmeg5t6sk.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78351-w",
  "fulltext_url": null,
  "id": "afr9kmeg5t6sk",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78351-w",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Immune cells in cancer"
    ]
  ],
  "openalex": "W7221647569",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78351-w.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-13",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/afr9kmeg5t6sk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-78351-w",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78351-w"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immune cells in cancer",
      "subfield": "immunology"
    }
  ],
  "title": "CD200+ fibroblasts prime the immunoregulatory function of granulocytic myeloid-derived suppressor cells in inflammatory arthritis",
  "title_text": "CD200+ fibroblasts prime the immunoregulatory function of granulocytic myeloid-derived suppressor cells in inflammatory arthritis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/afr9kmeg5t6sk",
  "venue": "Nature Communications",
  "versions": []
}