{
  "abstract": "Purpose: Overweight and obesity may alter endogenous estrogen exposure in women, yet evidence on the effects of aerobic exercise alone remains limited. This systematic review and meta-analysis aimed to evaluate the effects of aerobic exercise on endogenous estrogen profiles and body composition in adult women with overweight or obesity. Methods: We systematically searched PubMed, Web of Science, Scopus, Embase, and the Cochrane Library for randomized controlled trials involving women aged ≥ 18 years with BMI ≥ 25 kg/m² who received aerobic exercise or aerobic exercise-based interventions. Random-effects meta-analyses used the DerSimonian-Laird estimator with Hartung-Knapp adjustment; subgroup analyses, meta-regression, sensitivity analyses, publication-bias assessment, and GRADE were also performed. Results: Fifteen trials involving 1217 participants were included. Aerobic exercise was associated with lower E₂ (Hedges' g = -0.22, 95% CI -0.38 to -0.06, p < 0.05), E₁ (g = -0.19, 95% CI -0.33 to -0.04, p < 0.05), and free E₂ (g = -0.18, 95% CI -0.33 to -0.04, p < 0.05), and with higher SHBG (g = 0.49, 95% CI 0.06 to 0.92, p < 0.05). Aerobic exercise was also associated with reductions in body weight (MD = -3.06, 95% CI -4.60 to -1.51, p < 0.05), BMI (MD = -1.48, 95% CI -2.91 to -0.06, p < 0.05), waist circumference (MD = -2.50, 95% CI -3.59 to -1.41, p < 0.05), and total fat mass (MD = -2.30, 95% CI -3.48 to -1.12, p < 0.05). Heterogeneity was substantial for several outcomes, and the certainty of evidence ranged from moderate to very low. Conclusions: These findings suggest that aerobic exercise may be associated with changes in estrogen bioavailability and reductions in body composition measures, but the evidence remains preliminary.",
  "abstract_shown": true,
  "affiliations": [
    "School of Sports Training, Tianjin University of Sport, Tianjin 301617, China.",
    "Department of Winter Sports, Hebei Sport University, Shijiazhuang 050041, China.",
    "Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311121, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chao Xie"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mingnan Zhuang"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiansong Huang",
      "orcid": "0000-0003-0821-2801"
    },
    {
      "affs": [
        1
      ],
      "name": "Yiran Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ag2gwarcs9bd9.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16100725",
  "fulltext_url": "https://europepmc.org/articles/PMC13707349",
  "id": "ag2gwarcs9bd9",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://europepmc.org/article/MED/42941201",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer Risks and Factors"
    ]
  ],
  "openalex": "W7214634612",
  "pdf_url": "https://europepmc.org/articles/PMC13707349?pdf=render",
  "pmcid": "PMC13707349",
  "pmid": "42941201",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ag2gwarcs9bd9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42941201",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42941201"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Risks and Factors",
      "subfield": "oncology"
    }
  ],
  "title": "Effects of Aerobic Exercise on Endogenous Estrogens and Body Composition in Women with Overweight or Obesity: A Systematic Review and Meta-Analysis.",
  "title_text": "Effects of Aerobic Exercise on Endogenous Estrogens and Body Composition in Women with Overweight or Obesity: A Systematic Review and Meta-Analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/ag2gwarcs9bd9",
  "venue": "Metabolites",
  "versions": []
}