{
  "abstract": "Background: Critical congenital heart disease (CCHD) is a leading cause of neonatal morbidity and mortality. Early detection is crucial to prevent life-threatening complications. Pulse oximetry screening (POS) is a noninvasive method to identify hypoxemia indicative of CCHD, but the optimal timing for screening remains debated. Aim: To evaluate the diagnostic accuracy of dual POS performed at 24–36 h and 48–72 h of life for early detection of CCHD in neonates. Methods: This prospective observational study was conducted over 20 months at a tertiary care neonatal intensive care unit (NICU) in India. A total of 1431 neonates, including term and preterm, underwent POS at two time points. Screening followed the modified American Academy of Pediatrics algorithm, with echocardiographic follow-up for positive screens. Sensitivity, specificity, positive predictive value, and negative predictive value (NPV) were calculated. Results: Of the enrolled neonates (n = 1431), dual screening identified 95 positives (6.64%): 11 CCHD, 38 noncritical CHD and 46 noncardiac hypoxemic conditions. Dual POS had higher sensitivity (73.33% vs. 60%) and NPV (99.7% vs. 99.54%), and a lower false-negative rate (26.66% vs. 40%). POS 2 detected 2 additional CCHDs missed by POS1. Among 1336 negatives, clinical follow-up found 4 CCHDs. Conclusion: Dual POS significantly improves CCHD detection over single screening while identifying treatable noncardiac hypoxemic conditions. This nurse-led protocol is feasible even in resource-constrained NICUs, warranting routine adoption alongside clinical examination to minimize missed diagnoses of CCHD.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Neha Singh"
    },
    {
      "name": "Jaya Upadhyay"
    },
    {
      "name": "Monica Lazarus"
    },
    {
      "name": "Shishir Soni"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ag5190mrpvtcx.bib",
  "cited_by": 0,
  "doi": "10.4103/heartviews.heartviews_17_26",
  "fulltext_url": "https://www.ovid.com/jnls/hrtv/fulltext/10.4103/heartviews.heartviews_17_26~should-dual-pulse-oximetry-screening-be-used-in-neonates-the",
  "id": "ag5190mrpvtcx",
  "issns": [
    "1995-705X",
    "0976-5123"
  ],
  "landing_url": "https://doi.org/10.4103/heartviews.heartviews_17_26",
  "language": "en",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC666-701"
    ],
    [
      "openalex",
      "2713|Congenital Heart Disease Studies"
    ]
  ],
  "openalex": "W7208725713",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Wolters Kluwer Medknow Publications",
  "ris": "https://research.draconitic.com/paper/ag5190mrpvtcx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:00Z",
      "native_id": "d4539e5e1dfc4d058f8cf72e3e088595",
      "source": "doaj",
      "url": "https://doi.org/10.4103/heartviews.heartviews_17_26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Congenital Heart Disease Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Should Dual Pulse Oximetry Screening Be Used in Neonates? The Insights from the CHOOSE Study",
  "title_text": "Should Dual Pulse Oximetry Screening Be Used in Neonates? The Insights from the CHOOSE Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:00Z",
  "url": "https://research.draconitic.com/paper/ag5190mrpvtcx",
  "venue": "Heart Views",
  "versions": []
}