{
  "abstract": "Adolescent Idiopathic Scoliosis (AIS) is a common three-dimensional spinal deformity, and its comorbidity with psychological disorders such as anxiety and depression is increasingly attracting clinical and research attention. This narrative review aims to summarize the epidemiological characteristics of this comorbidity in AIS. It explores the complex underlying psychophysiological interaction mechanisms, including psychosocial stress, chronic pain, body image disturbance, and interconnected neuroendocrine and neuroimmune pathways. Based on this mechanistic understanding, the article further synthesizes and evaluates existing intervention strategies for this comorbid condition, encompassing psychological therapies, pharmacotherapy, physical rehabilitation, and emerging multidisciplinary integrated care models. Finally, the review outlines future research directions, with the goal of providing a theoretical foundation and a comprehensive management framework to improve the holistic physical and mental health outcomes for individuals with AIS.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedics and Traumatology, Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine",
    "Department of Orthopedics and Traumatology, Yancheng TCM Hospital",
    "Department of Pharmacology, School of Basic Medical Science, Nanjing Medical University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Zhaomeng Hou"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiaojiao Wu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hua Lu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chaoqun Chen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jing Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tingliang Han"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/agepsrw6as1e2.bib",
  "cited_by": 0,
  "doi": "10.3389/fpsyt.2026.1878400",
  "fulltext_url": null,
  "id": "agepsrw6as1e2",
  "issns": [
    "1664-0640"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1878400/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Scoliosis diagnosis and treatment"
    ]
  ],
  "openalex": "W7224115344",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/agepsrw6as1e2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:18Z",
      "native_id": "10.3389/fpsyt.2026.1878400",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1878400/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Scoliosis diagnosis and treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Adolescent idiopathic scoliosis and comorbid anxiety and depression: advances in psychophysiological interaction mechanisms and integrated interventions",
  "title_text": "Adolescent idiopathic scoliosis and comorbid anxiety and depression: advances in psychophysiological interaction mechanisms and integrated interventions",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:18Z",
  "url": "https://research.draconitic.com/paper/agepsrw6as1e2",
  "venue": "Frontiers in Psychiatry",
  "versions": []
}