{
  "abstract": "Background\n\nPeri- and epicardial adipose tissue (PEAT) is a metabolically active fat depot surrounding the heart and coronary arteries that may contribute to vascular dysfunction and inflammation in type 2 diabetes (T2D). We examined associations between PEAT volume, coronary calcification (CACS), myocardial flow reserve (MFR), and systemic inflammation (hsCRP).Methods\n\nCross-sectional analysis of adults with T2D without overt CVD recruited 2020-2023. PEAT was quantified on non-contrast CT; CACS was calculated by the Agatston method; MFR was measured by rubidium-82 PET/CT; hsCRP assessed systemic inflammation. Associations were tested using multivariable regression adjusting for cardiovascular risk factors.Results\n\nAmong 887 participants (mean age 65 years; 70% male; mean BMI 30 kg/m²; median PEAT 199 mL [IQR 133-283]), higher PEAT (per 100 mL) was associated with lower MFR (β - 0.04; 95% CI - 0.09 to 0.00; p = 0.041) and higher hsCRP, corresponding to a 38% increase (95% CI 28% to 48%; p < 0.001) in age- and sex-adjusted models, but not with CACS > 300 (OR 1.01; 95% CI 0.89-1.15). After further adjustment for diabetes duration, BMI, LDL cholesterol, systolic blood pressure, HbA1c, kidney function, smoking, and albuminuria, only the association with hsCRP remained significant at 14% (95%; CI 4% to 25%; p = 0.005).Conclusion\n\nIn individuals with T2D without overt CVD, PEAT volume was not independently associated with CACS or MFR after multivariable adjustment. Higher PEAT volume was associated with higher hsCRP, suggesting a relationship with systemic inflammation; however, this exploratory finding should be interpreted in the context of established links between adiposity and inflammatory burden.",
  "abstract_shown": true,
  "affiliations": [
    "Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.",
    "Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.",
    "Department of Cardiology, Herlev & Gentofte Hospital, Hellerup, Denmark.",
    "Department of Internal Medicine 1, Holbæk Hospital, Holbæk, Denmark.",
    "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.",
    "Department of Medicine, Zealand University Hospital, Nykøbing Falster, Denmark.",
    "Steno Diabetes Center Zealand, Zealand, Denmark.",
    "Department of Medicine, Zealand University Hospital, Køge, Denmark.",
    "Department of Cardiology, Rigshospitalet, Denmark.",
    "Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark.",
    "Cluster for Molecular Imaging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.",
    "Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark. tine.willum.hansen@regionh.dk.",
    "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. tine.willum.hansen@regionh.dk."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Morten Steen Jensen"
    },
    {
      "affs": [
        0
      ],
      "name": "Ida K B Rasmussen"
    },
    {
      "affs": [
        0
      ],
      "name": "Anne-Cathrine Skriver-Møller"
    },
    {
      "affs": [
        1
      ],
      "name": "Philip Hasbak"
    },
    {
      "affs": [
        0
      ],
      "name": "Martin B Blond",
      "orcid": "0000-0002-2032-1560"
    },
    {
      "affs": [
        0
      ],
      "name": "Adam Chebli"
    },
    {
      "affs": [
        0
      ],
      "name": "Victor S Wasehuus"
    },
    {
      "affs": [
        2
      ],
      "name": "Mats C H Lassen"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Morten Lindhardt"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Allan Kofoed-Enevoldsen"
    },
    {
      "affs": [
        7,
        6
      ],
      "name": "Urd L Kielgast"
    },
    {
      "affs": [
        0
      ],
      "name": "Emilie H Zobel"
    },
    {
      "affs": [
        4,
        8
      ],
      "name": "Lene Holmvang"
    },
    {
      "affs": [
        0,
        2,
        8
      ],
      "name": "Tor Biering-Sørensen"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Peter Rossing",
      "orcid": "0000-0002-1531-4294"
    },
    {
      "affs": [
        4,
        9,
        10
      ],
      "name": "Rasmus S Ripa",
      "orcid": "0000-0003-2035-2321"
    },
    {
      "affs": [
        1,
        10
      ],
      "name": "Andreas Kjaer",
      "orcid": "0000-0002-2706-5547"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Tine W Hansen",
      "orcid": "0000-0003-2274-0352"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/agfydeww6qyec.bib",
  "cited_by": 0,
  "doi": "10.1186/s12933-026-03298-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13682117",
  "id": "agfydeww6qyec",
  "issns": [
    "1475-2840"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897624",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC666-701"
    ],
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      "openalex",
      "2705|Cardiovascular Disease and Adiposity"
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  "pdf_url": "https://europepmc.org/articles/PMC13682117?pdf=render",
  "pmcid": "PMC13682117",
  "pmid": "42897624",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/agfydeww6qyec.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
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      "origin": "openalex:2705|Cardiovascular Disease and Adiposity",
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  "title": "Associations between cardiac adipose tissue volume, measures of coronary calcification, myocardial microvascular function and systemic inflammation in individuals with type 2 diabetes free of overt cardiovascular disease.",
  "title_text": "Associations between cardiac adipose tissue volume, measures of coronary calcification, myocardial microvascular function and systemic inflammation in individuals with type 2 diabetes free of overt cardiovascular disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:38Z",
  "url": "https://research.draconitic.com/paper/agfydeww6qyec",
  "venue": "Cardiovascular diabetology",
  "versions": []
}