{
  "abstract": "Background: Left ventricular/left ventricle (LV) overload remains a major limitation of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock. Left atrial veno-arterial extracorporeal membrane oxygenation (LAVA-ECMO) has been proposed to facilitate LV unloading; however, data regarding its optimal timing and clinical role remain limited.\n\nMethods: This single-center retrospective cohort study evaluated the efficacy and safety of a preventive single-inflow cannula LAVA-ECMO strategy, defined as an a priori LV unloading approach implemented at extracorporeal membrane oxygenation (ECMO) initiation, either through primary LAVA-ECMO implantation or planned early conversion from VA-ECMO within 60 minutes. Between January 2020 and July 2025, eligible patients supported with VA-ECMO or LAVA-ECMO were screened. After predefined exclusions, 42 patients managed with preventive LAVA-ECMO were compared with 64 contemporaneous patients receiving conventional VA-ECMO.\n\nResults: Thirty-day all-cause mortality was lower in the LAVA-ECMO group than in the VA-ECMO group (47.6% vs 76.6%; adjusted hazard ratio, 0.54; 95% CI, 0.31-0.95). Failure to wean from ECMO tended to occur less frequently with LAVA-ECMO (31.0% vs 56.3%; adjusted odds ratio, 0.43; 95% CI, 0.18-1.01). Signs of LV overload during ECMO support were significantly reduced in the LAVA-ECMO group (47.6% vs 82.8%; adjusted odds ratio, 0.19, 95% CI, 0.08-0.49). Overall complication rates were comparable between groups.\n\nConclusions: In this retrospective cohort, preventive LAVA-ECMO was associated with lower short-term mortality and a reduced incidence of LV overload without an apparent increase in complications. Preventive LAVA-ECMO may represent a feasible mechanical circulatory support strategy in carefully selected patients with cardiogenic shock.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Cardiovascular Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan",
    "Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan",
    "Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan",
    "Division of Cardiology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan",
    "Division of Cardiovascular Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Yu-Tsung Shih"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Hung-Chang Jong"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Chia-Cheng Lin"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Bu-Yuan Hsiao"
    },
    {
      "affs": [
        4
      ],
      "name": "Chung-Ming Tu"
    },
    {
      "affs": [
        4
      ],
      "name": "Jung-Cheng Hsu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Ta-Jung Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/agm9sgvjxf7kv.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jscai.2026.105518",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13700037/",
  "id": "agm9sgvjxf7kv",
  "issns": [
    "2772-9303"
  ],
  "landing_url": "https://doi.org/10.1016/j.jscai.2026.105518",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2204|Mechanical Circulatory Support Devices"
    ]
  ],
  "openalex": "W7212124764",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13700037/pdf/?tool=EBI",
  "pmcid": "PMC13700037",
  "pmid": "42936608",
  "published": "2026-09-10",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/agm9sgvjxf7kv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "PMC13700037",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jscai.2026.105518"
    },
    {
      "first_seen": "2026-10-30T12:21:51Z",
      "native_id": "PMC:PMC13700037",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13700037"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Utilization of Preventive Single-Inflow Cannula Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock",
  "title_text": "Utilization of Preventive Single-Inflow Cannula Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:36:31Z",
  "url": "https://research.draconitic.com/paper/agm9sgvjxf7kv",
  "venue": "Journal of the Society for Cardiovascular Angiography & Interventions",
  "versions": []
}