{
  "abstract": "The first enantioselective benzylic C–H insertion using α-alkyl-α-diazoesters, facilitated by a well-established chiral dirhodium­(II) catalyst, is presented. This reaction selectively functionalizes primary benzylic C–H bonds with good to excellent enantioselectivity (up to 95% ee), thereby demonstrating the synthetic utility of this previously underexplored class of diazo reagents. The resulting differentiated diester products undergo selective monoester removal, thereby enabling subsequent functional-group manipulation of the liberated carboxylic acid and expanding access to enantioenriched building blocks.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry and Biochemistry, College of Arts and Sciences, Kent State University, Kent, Ohio 44242, United States",
    "Department of Chemistry, Faculty of Science and Technology, University of Nairobi, Nairobi 00100, Kenya"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nicholas M. Kamuti",
      "orcid": "0009-0008-9747-3651"
    },
    {
      "affs": [
        0
      ],
      "name": "Bijaya Bagale"
    },
    {
      "affs": [
        0
      ],
      "name": "Scott D. Bunge"
    },
    {
      "affs": [
        1
      ],
      "name": "Albert J. Ndakala"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeffrey D. Mighion",
      "orcid": "0000-0001-6908-5186"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/agtfe3ne5xr35.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c03819",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13711632/",
  "id": "agtfe3ne5xr35",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://doi.org/10.1021/acs.orglett.6c03819",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Letter"
    ],
    [
      "openalex",
      "1605|Cyclopropane Reaction Mechanisms"
    ]
  ],
  "openalex": "W7221065732",
  "pdf_url": "https://pubs.acs.org/orlef7/article-pdf/doi/10.1021/acs.orglett.6c03819/68809905/acs.orglett.6c03819.pdf",
  "pmcid": "PMC13711632",
  "pmid": "42925190",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/agtfe3ne5xr35.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:22Z",
      "native_id": "PMC13711632",
      "source": "pmc",
      "url": "https://doi.org/10.1021/acs.orglett.6c03819"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Cyclopropane Reaction Mechanisms",
      "subfield": "organic"
    }
  ],
  "title": "Enantioselective Benzylic C–H Insertions with Diazosuccinate Esters",
  "title_text": "Enantioselective Benzylic C–H Insertions with Diazosuccinate Esters",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:22Z",
  "url": "https://research.draconitic.com/paper/agtfe3ne5xr35",
  "venue": "Organic Letters",
  "versions": []
}