{
  "abstract": "Zika virus (ZIKV) is an arthropod-borne flavivirus endemic to Latin America, Africa, and Southeast Asia for which IgG-mediated antibody-dependent enhancement of infectivity (ADE) is a phenomenon of concern. The dynamics between flavivirus-specific antibodies of the IgG and IgM isotypes are mostly unknown. Here, we used DH1017.IgM, a previously described human-derived, pentameric, ultrapotent neutralizing ZIKV IgM monoclonal antibody (mAb) and a recombinantly produced IgM version of neutralizing EDE1 mAb C8 (C8.IgM) to assess if IgM antibodies can interfere with IgG-mediated ADE in vitro. Both mAbs consistently reduced IgG-mediated ADE across a panel of ZIKV-binding IgG mAbs in a dose-dependent manner. ADE mitigation was achieved at DH1017.IgM sub-neutralizing concentrations. C8.IgM also mitigated IgG-mediated ADE for ZIKV and dengue virus (DENV), demonstrating generalizability. Finally, DH1017.IgM confirmed inhibition of ADE at sub-neutralizing concentrations in sera of ZIKV-infected individuals. In conclusion, mAbs of the IgM isotype may potently counter the adverse effects of IgG-mediated ADE.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Matthias Lingemann"
    },
    {
      "name": "Taylor J. McGee"
    },
    {
      "name": "Giacomo Sidoti Migliore"
    },
    {
      "name": "Jenna M. DeLuca"
    },
    {
      "name": "Stephen S. Whitehead"
    },
    {
      "name": "Mattia Bonsignori",
      "orcid": "0000-0003-2973-2101"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/agyyn8gbqt4p1.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117897",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13697329/",
  "id": "agyyn8gbqt4p1",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03280-3",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Immunology"
    ],
    [
      "heading",
      "Microbiology"
    ],
    [
      "heading",
      "Virology"
    ],
    [
      "openalex",
      "2739|Mosquito-borne diseases and control"
    ]
  ],
  "openalex": "W7222976829",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13697329/pdf/?tool=EBI",
  "pmcid": "PMC13697329",
  "pmid": "42935869",
  "published": "2026-10-19",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/agyyn8gbqt4p1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117897",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03280-3"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117897",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226032803"
    },
    {
      "first_seen": "2026-10-30T12:18:24Z",
      "native_id": "PMC13697329",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.117897"
    },
    {
      "first_seen": "2026-10-30T12:21:25Z",
      "native_id": "PMC:PMC13697329",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13697329"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Immunology",
      "subfield": "immunology"
    },
    {
      "field": "biology",
      "origin": "heading:Microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "IgM monoclonal antibodies reduce IgG-mediated antibody-dependent enhancement of Zika and dengue virus infectivity",
  "title_text": "IgM monoclonal antibodies reduce IgG-mediated antibody-dependent enhancement of Zika and dengue virus infectivity",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:23Z",
  "url": "https://research.draconitic.com/paper/agyyn8gbqt4p1",
  "venue": "iScience",
  "versions": []
}