{
  "abstract": "Background/Objectives: Plant-derived ingredients have attracted interest as adjuncts for reducing body fat, but clinical evidence for Lythrum salicaria extract alone remains limited. We evaluated its effects on body fat and its safety in adults with a body mass index (BMI) of 23–30 kg/m2. Methods: Ninety adults aged 19–75 years participated in a single-center, randomized, double-blind, placebo-controlled trial. Participants received either 500 mg/day of L. salicaria extract powder (corresponding to approximately 400 mg/day of plant-derived extract solids) or placebo for 12 weeks. The primary endpoint was the change in body fat mass from baseline to day 84, assessed by dual-energy X-ray absorptiometry (DXA). Efficacy was evaluated primarily in the per-protocol (PP) population, with supporting intention-to-treat (ITT) analyses. Anthropometric measures, other DXA outcomes, and blood markers were assessed as secondary endpoints. Results: The PP population included 84 participants. Baseline-adjusted differences in body fat mass change, expressed as extract minus placebo, were −2.01 kg (95% confidence interval [CI], −2.51 to −1.52; p < 0.001) in the PP population and −2.04 kg (95% CI, −2.66 to −1.42; p < 0.001) in the ITT population. Exploratory secondary analyses favored the extract for BMI, body weight, body fat percentage, and adiponectin. No serious adverse events occurred. Conclusions: Supplementation with L. salicaria extract powder for 12 weeks was associated with a reduction in DXA-measured body fat mass compared with placebo. Larger trials with longer follow-up are needed to confirm the findings and investigate the mechanisms involved.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Korean Medicine, The Graduate School, Pusan National University, Yangsan 50612, Republic of Korea",
    "Department of Korean Medicine Rehabilitation, Pusan National University Korean Medicine Hospital, 20 Geumo-ro, Mulgeum-eup, Yangsan 50612, Republic of Korea",
    "Department of Rehabilitation Medicine of Korean Medicine, Se-Myung University Chungju Korean Medicine Hospital, 63 Sangbang 4-gil, Chungju 27429, Republic of Korea",
    "Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Sangji University, 80 Sangjidae-gil, Wonju 26338, Republic of Korea",
    "College of Pharmacy and Institute of Integrated Pharmaceutical Sciences, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea",
    "Department of Precision Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea",
    "Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea",
    "The School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Bong-Jin Shin",
      "orcid": "0000-0002-1074-9125"
    },
    {
      "affs": [
        2
      ],
      "name": "Hye-Jin Park"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Yea-Jin Park"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Hyo-Jin An",
      "orcid": "0000-0002-2937-874X"
    },
    {
      "affs": [
        6
      ],
      "name": "Su Shin",
      "orcid": "0000-0003-3110-9263"
    },
    {
      "affs": [
        3
      ],
      "name": "Yun-Yeop Cha"
    },
    {
      "affs": [
        1,
        7
      ],
      "name": "In Heo",
      "orcid": "0000-0003-2893-8917"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ah1c036xmy47r.bib",
  "cited_by": 0,
  "doi": "10.3390/nu18203342",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13708396/?tool=EBI",
  "id": "ah1c036xmy47r",
  "issns": [
    "2072-6643"
  ],
  "landing_url": "https://www.mdpi.com/2072-6643/18/20/3342",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Pharmacology and Obesity Treatment"
    ]
  ],
  "openalex": "W7221548647",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13708396/pdf/?tool=EBI",
  "pmcid": "PMC13708396",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/ah1c036xmy47r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:56Z",
      "native_id": "10.3390/nu18203342",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6643/18/20/3342"
    },
    {
      "first_seen": "2026-10-30T12:21:45Z",
      "native_id": "PMC:PMC13708396",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13708396"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Pharmacology and Obesity Treatment",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Efficacy and Safety of Lythrum salicaria Extract on Body Fat Reduction in Adults with a BMI of 23–30 kg/m2: A Randomized, Double-Blind, Placebo-Controlled Trial",
  "title_text": "Efficacy and Safety of Lythrum salicaria Extract on Body Fat Reduction in Adults with a BMI of 23–30 kg/m2: A Randomized, Double-Blind, Placebo-Controlled Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:45Z",
  "url": "https://research.draconitic.com/paper/ah1c036xmy47r",
  "venue": "Nutrients",
  "versions": []
}