{
  "abstract": "Neurons, glial cells, and immune cells engage in extensive bidirectional communication within the central nervous system (CNS) through shared receptors, ligands, and secreted mediators. Glial cells — particularly astrocytes and microglia — serve not merely as structural support but as central immunomodulatory hubs that relay neural signals to immune effectors. In the context of CNS malignancies, glioblastoma (GBM) co-opts these neuroimmune networks to establish an immunosuppressive tumor microenvironment. This narrative review is organized around five interconnected axes. After summarizing the receptor and ligand repertoires of CNS-resident cell types, we examine (i) the neural inputs that reach glioblastoma and the reciprocal signals the tumor returns to the neural compartment; (ii) the remodeling of glial cells and glioma-associated macrophages/microglia; (iii) the innate and adaptive immune suppression that follows, including a “chemical–cellular” suppressive architecture; (iv) the blood–brain barrier and neurovascular interface that constrain immune access; and (v) the therapeutic opportunities arising from each of these layers.",
  "abstract_shown": true,
  "affiliations": [
    "Cell Therapy Research Center, Xiamen Humanity Hospital",
    "School of Medicine, Xiamen University",
    "Department of Radiology, The Second Affiliated Hospital of Xiamen Medical College"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yanfei Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiuhong Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Xianwu Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Huaian Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiancheng Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Lili Yao"
    },
    {
      "affs": [
        0
      ],
      "name": "Junyan Lin"
    },
    {
      "affs": [
        2
      ],
      "name": "Rui Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ah82qt2kmwcyg.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.2002570",
  "fulltext_url": null,
  "id": "ah82qt2kmwcyg",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.2002570/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7224123188",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/ah82qt2kmwcyg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.2002570",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.2002570/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Glioma Diagnosis and Treatment",
      "subfield": "human-genetics"
    }
  ],
  "title": "Neuroimmune communication: from CNS-resident cell networks to the glioblastoma microenvironment",
  "title_text": "Neuroimmune communication: from CNS-resident cell networks to the glioblastoma microenvironment",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:17Z",
  "url": "https://research.draconitic.com/paper/ah82qt2kmwcyg",
  "venue": "Frontiers in Immunology",
  "versions": []
}