{
  "abstract": "Food safety requires rapid, sensitive and reliable methods for detecting contaminants in complex food matrices. Metal-organic frameworks (MOFs), owing to their high surface areas, tunable pores and abundant functional sites, have shown considerable potential in food sensing and sample pretreatment. Recently, MOF-on-MOF heterostructures have attracted increasing attention because their hierarchical architectures and tunable interfaces can integrate complementary adsorption, catalytic and signal-transduction functions. This review summarizes the major construction strategies and structural types of MOF-on-MOF materials, with emphasis on epitaxial growth, seed-mediated assembly, interfacial engineering and post-synthetic conversion. Particular attention is given to the distinction between intact MOF-on-MOF heterostructures, MOF-on-MOF-derived materials and related MOF-based hybrids. Recent applications in electrochemical and optical sensing, biosensing-related platforms, and sample pretreatment by magnetic solid-phase extraction (MSPE), solid-phase microextraction (SPME) and dispersive micro-solid-phase extraction (DµSPE) are critically reviewed, together with emerging applications in food preservation and freshness monitoring. Structure-function relationships and analytical performance are discussed beyond sensitivity alone, considering matrix effects, selectivity, reproducibility and stability. Finally, current challenges in mechanistic understanding, material safety, batch-to-batch consistency and scalable fabrication are highlighted. Future priorities include robust real-matrix validation, reproducible synthesis, portable multimodal analysis and more sustainable fabrication, providing guidance for the practical development of MOF-on-MOF materials in food-safety analysis.",
  "abstract_shown": true,
  "affiliations": [
    "College of Physical Education, South China Agricultural University Zhujiang College Guangzhou 510900 China.",
    "Shanghai University of Sport Changhai Road 399 Shanghai 200438 China liubing2019@sus.edu.cn lizhongquan@sus.edu.cn."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhen Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Tingyuan Zheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiahui Cheng",
      "orcid": "0009-0000-3063-6470"
    },
    {
      "affs": [
        1
      ],
      "name": "Bing Liu",
      "orcid": "0000-0002-6337-3774"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhongquan Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ahcnwkhhqa0qv.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra07322k",
  "fulltext_url": "https://europepmc.org/articles/PMC13646915",
  "id": "ahcnwkhhqa0qv",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42851948",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1604|Metal-Organic Frameworks: Synthesis and Applications"
    ]
  ],
  "openalex": "W7221032139",
  "pdf_url": "https://europepmc.org/articles/PMC13646915?pdf=render",
  "pmcid": "PMC13646915",
  "pmid": "42851948",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ahcnwkhhqa0qv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "MED:42851948",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42851948"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1604|Metal-Organic Frameworks: Synthesis and Applications",
      "subfield": "inorganic"
    }
  ],
  "title": "MOF-on-MOF heterostructured composites for food safety analysis: construction strategies, sensing applications and sample pretreatment.",
  "title_text": "MOF-on-MOF heterostructured composites for food safety analysis: construction strategies, sensing applications and sample pretreatment.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/ahcnwkhhqa0qv",
  "venue": "RSC advances",
  "versions": []
}