{
  "abstract": "Here, we report an iron-catalyzed aerobic transformation that activates N/O/S-α-C(sp3)–H bonds under blue light irradiation, forming hemiacetal-type analogues, amenable for trapping with diverse commercially available N-, O-, S-, and C-nucleophiles. The method achieves azolation, amination, acetalization, hydroxylation, thiolation, alkylation, and arylations across ethers, thioethers and pyrrolidines with high chemoselectivity and regioselectivity. Mechanistic studies indicate that this system synergizes iron-catalyzed photoinduced LMCT, followed by chlorine radical-initiated HAT and subsequent O2 trapping of the resulting alkyl radicals to afford key hemiacetal-type intermediates. Significantly, FeCl3 serves a triple catalytic role by generating chlorine radicals, functioning as a redox shuttle and acting as a Lewis acid activator.",
  "abstract_shown": true,
  "affiliations": [
    "College of Chemistry and Molecular Sciences, Henan University Kaifeng 475004 P. R. China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xinlong Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiayin Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Nan Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingjing Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Baokun Qiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hegui Gong"
    },
    {
      "affs": [
        0
      ],
      "name": "Pan Li",
      "orcid": "0000-0001-6658-9207"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aj8ywq0r6hrff.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc05655e",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13592431/",
  "id": "aj8ywq0r6hrff",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://doi.org/10.1039/d6sc05655e",
  "language": "en",
  "licence": "CC-BY-3.0",
  "licence_label": "CC BY 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Catalytic C–H Functionalization Methods"
    ]
  ],
  "openalex": "W7213562724",
  "pdf_url": "https://pubs.rsc.org/sc/article-pdf/doi/10.1039/D6SC05655E/14733958/d6sc05655e.pdf",
  "pmcid": "PMC13592431",
  "pmid": "42770088",
  "published": "2026-09-18",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/aj8ywq0r6hrff.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:23:30Z",
      "native_id": "PMC13592431",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc05655e"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic C–H Functionalization Methods",
      "subfield": "organic"
    }
  ],
  "title": "Oxygen-enabled Fe-catalyzed heteroatom α-C(sp3)–H functionalization with nucleophiles",
  "title_text": "Oxygen-enabled Fe-catalyzed heteroatom α-C(sp3)–H functionalization with nucleophiles",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:59Z",
  "url": "https://research.draconitic.com/paper/aj8ywq0r6hrff",
  "venue": "Chemical Science",
  "versions": []
}