{
  "abstract": "Radiation-induced bystander effects (RIBEs) compromise radioprotection and radiotherapy by propagating damage to non-irradiated cells; however, the mediators and underlying circuitry remain incompletely defined. Using localised UV irradiation as the primary experimental system and localised X-ray irradiation as a supportive test in an in vivo Caenorhabditis elegans model, we identify tyramine, a trace amine structurally and functionally related to adrenaline/noradrenaline, as a neuron-derived mediator of RIBEs. Tyramine released from tyraminergic RIM neurons activates TYRA-3, a tyramine-responsive adrenergic-like GPCR related to vertebrate adrenergic receptors. This neuron-to-intestine signal promotes secretion of the insulin-like peptide INS-5, aberrantly engages the DAF-2/insulin signalling pathway (IIS), and triggers endoplasmic reticulum stress, DNA damage responses, and embryonic lethality in non-irradiated tissues. These findings reveal a neuro–intestinal–germline axis that orchestrates RIBEs and uncover an unanticipated role for adrenaline-like signalling. Our work provides a conceptual framework for systematically discovering additional RIBE mediators and identifies pathway components for future evaluation as radioprotective or radiotherapy-modifying targets.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "Zirui Huang",
      "orcid": "0000-0002-0822-352X"
    },
    {
      "name": "Jiane-Kang Liu"
    },
    {
      "name": "Wenyuan He",
      "orcid": "0009-0005-6809-0115"
    },
    {
      "name": "Longnong You"
    },
    {
      "name": "Lizhu Zhang"
    },
    {
      "name": "Yongsheng Chen",
      "orcid": "0009-0001-4642-5798"
    },
    {
      "name": "Yaoyong Zeng"
    },
    {
      "name": "Yuxin Guo"
    },
    {
      "name": "Haiyang Yu"
    },
    {
      "name": "Junbu Li"
    },
    {
      "name": "Shiming Li",
      "orcid": "0000-0003-0116-2493"
    },
    {
      "name": "Xinyu Tao"
    },
    {
      "name": "Peng Falcon Liu"
    },
    {
      "name": "Bin Liu"
    },
    {
      "name": "Chao Zhao",
      "orcid": "0000-0003-1096-632X"
    },
    {
      "name": "Lingjun Zheng",
      "orcid": "0000-0002-3350-8498"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ajjaqy9qyxewb.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78815-z",
  "fulltext_url": null,
  "id": "ajjaqy9qyxewb",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78815-z",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Effects of Radiation Exposure"
    ]
  ],
  "openalex": "W7223413737",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78815-z_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/ajjaqy9qyxewb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-78815-z",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78815-z"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Effects of Radiation Exposure",
      "subfield": "imaging"
    }
  ],
  "title": "Tyramine mediates radiation-induced bystander effects",
  "title_text": "Tyramine mediates radiation-induced bystander effects",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/ajjaqy9qyxewb",
  "venue": "Nature Communications",
  "versions": []
}