{
  "abstract": "Background: Genotype-resolved data on human papillomavirus (HPV) are almost absent for Venezuelan indigenous women. Methods: We studied 260 women from La Guajira (Wayuu, n = 94), Maniapure (Eñepa, n = 141), and Delta Amacuro (Warao, n = 25), processing all self-collected samples with a single real-time PCR assay that resolves 21 genotypes; cytology was available for 144. Results: HPV prevalence was 55.4% (95% CI 49.3-61.3) and high-risk prevalence was 51.2% (95% CI 45.1-57.2), rising from 42.6% in La Guajira to 59.6% in Maniapure and 80.0% in Delta Amacuro (p = 0.001). Nineteen genotypes were detected. HPV-31 was most frequent (15.8%), followed by HPV-16 (11.5%), and each community had its own profile, with HPV-68 and HPV-56 leading in Delta Amacuro. Half of the infected women carried more than one type. Cytology and HPV testing overlapped little: 20 of 78 HPV-positive women with a smear (25.6%) had an abnormal result (κ = 0.056). At least one nonavalent vaccine type was present in 69.4% of infected women, compared with 30.6% for the bivalent vaccine. Conclusions: HPV vaccination is not part of the Venezuelan national program; these data favor the nonavalent formulation, and HPV-based screening would need a feasible triage pathway for the many women who test positive.",
  "abstract_shown": true,
  "affiliations": [
    "Escuela de Bioanálisis \"Dr. Rafael Rangel\", Faculty of Medicine, Universidad Central de Venezuela, Caracas 1040, Venezuela.",
    "Escuela de Medicina \"Luis Razetti\", Faculty of Medicine, Universidad Central de Venezuela, Caracas 1040, Venezuela.",
    "Gynecology Department, Hospital Universitario de Caracas, Escuela de Medicina \"Luis Razetti\", Faculty of Medicine, Universidad Central de Venezuela, Caracas 1040, Venezuela.",
    "Instituto Anatomopatológico \"Dr. José Antonio O'Daly\", Faculty of Medicine, Universidad Central de Venezuela, Caracas 1040, Venezuela.",
    "Instituto Nacional de Higiene \"Rafael Rangel\", Ministry of Popular Power for Health, Caracas 1050, Venezuela.",
    "Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, 779 00 Olomouc, Czech Republic.",
    "Instituto de Inmunología \"Dr. Nicolás Enrique Bianco C.\", Faculty of Medicine, Universidad Central de Venezuela, Caracas 1040, Venezuela."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "María Fátima Garcés",
      "orcid": "0000-0002-5113-598X"
    },
    {
      "affs": [
        0
      ],
      "name": "Jefferson Guzmán Silva",
      "orcid": "0009-0007-8628-3070"
    },
    {
      "affs": [
        1
      ],
      "name": "Daniel Aranguren",
      "orcid": "0000-0003-0692-8240"
    },
    {
      "affs": [
        2
      ],
      "name": "Lina Figueira"
    },
    {
      "affs": [
        2
      ],
      "name": "Ricardo Blanch"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Marwan Said Aguilar Mejía",
      "orcid": "0000-0002-7100-3941"
    },
    {
      "affs": [
        0
      ],
      "name": "Yacelli Bustamante Siberio",
      "orcid": "0000-0003-2889-7959"
    },
    {
      "affs": [
        5
      ],
      "name": "Juan Bautista De Sanctis",
      "orcid": "0000-0002-5480-4608"
    },
    {
      "affs": [
        6
      ],
      "name": "Alexis Hipólito García",
      "orcid": "0000-0002-2354-0160"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ajjaxwj9fsth7.bib",
  "cited_by": 0,
  "doi": "10.3390/diseases14100384",
  "fulltext_url": "https://europepmc.org/articles/PMC13703561",
  "id": "ajjaxwj9fsth7",
  "issns": [
    "2079-9721"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930011",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Cervical Cancer and HPV Research"
    ]
  ],
  "openalex": "W7211963327",
  "pdf_url": "https://europepmc.org/articles/PMC13703561?pdf=render",
  "pmcid": "PMC13703561",
  "pmid": "42930011",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ajjaxwj9fsth7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930011",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930011"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Cervical Cancer and HPV Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Divergent Human Papillomavirus Genotype Spectra in Three Indigenous Communities of Venezuela: Implications for Vaccine Choice and Cervical Screening.",
  "title_text": "Divergent Human Papillomavirus Genotype Spectra in Three Indigenous Communities of Venezuela: Implications for Vaccine Choice and Cervical Screening.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/ajjaxwj9fsth7",
  "venue": "Diseases (Basel, Switzerland)",
  "versions": []
}