{
  "abstract": "Aflatoxin B1 (AFB1) can impair broiler performance, redox balance, and skeletal health. This 42-day study evaluated whether partial replacement of conventional inorganic zinc (Zn) and selenium (Se) sources with nanoforms could mitigate AFB1-associated responses and compared this source-substitution strategy with the use of commercial toxin binder. A total of 792 day-old male Ross 308 broilers were allocated to six treatments (6 replicate pens/treatment, 22 birds/pen; pen served as the experimental unit): Control; AF (0.5 mg AFB1/kg); AF+TB (2 g toxin binder/kg); AF+NZ (40 mg Zn/kg supplied as nano-zinc in place of an equivalent amount from zinc sulfate); AF+NS (0.1 mg Se/kg supplied as nano-selenium in place of an equivalent amount from sodium selenite); and AF+NZ+NS (combined nano-Zn and nano-Se partial replacement). Supplemental Zn and Se were maintained at 120 and 0.3 mg/kg, respectively. Relative to AF, AF+TB and AF+NZ+NS increased body weight gain by 9.7% and 6.3%, feed efficiency by 6.8% and 5.7%, total antioxidant capacity by 37.6% and 34.5%, and serum GSH by 38.6% and 35.7%, respectively, while reducing serum MDA by 31.0% and 32.1% (P < 0.05). Both treatments also improved selected immunoglobulin measures, hepatic expression of NFE2L2, GPX1, and SOD1, culture-based bacterial counts, tibial length and tibia ash content, although AF+NZ+NS did not consistently outperform the single nano-mineral treatments and did not fully restore the control phenotype. Under the conditions of this 42-day, 0.5 mg/kg AFB1 challenge, combined partial replacement with nano-Zn and nano-Se improved several measured responses, including productive performance, antioxidant status, and tibia quality.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Animal Science, Faculty of Agriculture and Natural Resources, Ilam University, Pajouhesh Blvd, Ilam, Ilam, 6939177111, Iran.",
    "Department of Animal Science, Faculty of Agriculture and Environment, Arak University, Shahid Beheshti Street, Arak, Markazi Province, 38156-8-8349, Iran."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fouad Kadhim Mohsin"
    },
    {
      "affs": [
        0
      ],
      "name": "Kamran Taherpour"
    },
    {
      "affs": [
        1
      ],
      "name": "Hossein Ali Ghasemi",
      "orcid": "0000-0003-4616-7597"
    },
    {
      "affs": [
        0
      ],
      "name": "Hassan Shirzadi"
    },
    {
      "affs": [
        0
      ],
      "name": "Fatemeh Tavakolinasab"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ajpy2mtvtfgtq.bib",
  "cited_by": 0,
  "doi": "10.1016/j.vas.2026.100888",
  "fulltext_url": "https://europepmc.org/articles/PMC13677327",
  "id": "ajpy2mtvtfgtq",
  "issns": [
    "2451-943X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898093",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Mycotoxins in Agriculture and Food"
    ]
  ],
  "openalex": "W7220675291",
  "pdf_url": "https://europepmc.org/articles/PMC13677327?pdf=render",
  "pmcid": "PMC13677327",
  "pmid": "42898093",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ajpy2mtvtfgtq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898093",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898093"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Mycotoxins in Agriculture and Food",
      "subfield": "plant-biology"
    }
  ],
  "title": "Protective effects of nano-zinc and nano-selenium compared with a toxin binder in broiler chickens fed aflatoxin B1-contaminated diets through antioxidant, immune, and skeletal responses.",
  "title_text": "Protective effects of nano-zinc and nano-selenium compared with a toxin binder in broiler chickens fed aflatoxin B1-contaminated diets through antioxidant, immune, and skeletal responses.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/ajpy2mtvtfgtq",
  "venue": "Veterinary and animal science",
  "versions": []
}