{
  "abstract": "Background\n\nmiR-511 is a well-known tumor suppressor in many tumor types. However, whether miR-511 directly regulates EREG in non-small cell lung cancer (NSCLC) and the functional consequences of this regulation have not been investigated.Methods\n\nReal-time quantitative polymerase chain reaction (qRT-PCR) was used to measure miR-511 expression. The proliferation, invasion and migration abilities of NSCLC cell lines A549 and H460 were determined by CCK-8, colony formation, and Transwell assays. RNA-seq was used to screen the target genes of miR-511. A xenograft mouse model was established to validate the tumor-suppressive role of miR-511 in vivo.Results\n\nThe expression of miR-511 is significantly down-regulated in NSCLC tissues and cells. The inducing of miR-511 dramatically inhibit the proliferation, invasion and migration of NSCLC cells. TargetScan predicates that EREG might be a target gene of miR-511. Dual-luciferase reporter assay confirmed that miR-511 directly binds to the 3'-UTR of EREG. Induction of MiR-511 significantly down-regulated the mRNA and protein levels of EREG, thus validating the prediction. Moreover, rescue experiments show that EREG overexpression impairs the effect of miR-511 on suppressing the malignant phenotype of NSCLC cells. Furthermore, in vivo xenograft experiments demonstrated that miR-511 overexpression significantly suppressed NSCLC tumor growth and reduced EREG expression in tumor tissues.Conclusion\n\nmiR-511 inhibits the proliferation and metastasis of NSCLC by down-regulating the expression of EREG. The miR-511-EREG axis may provide a potential basis for future therapeutic exploration in NSCLC.",
  "abstract_shown": true,
  "affiliations": [
    "Taizhou Central Hospital (Taizhou University Hospital), Tai Zhou, 318000, P.R. China.",
    "Taizhou Central Hospital of Wenzhou Medical University, Tai Zhou, 318000, P.R. China.",
    "Department of Radiology, The first hospital of Tsinghua University, Bejing, 100016, P.R. China.",
    "Infectious Diseases Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan City, 250000, Shandong Province, P.R. China.",
    "Taizhou Central Hospital (Taizhou University Hospital), Tai Zhou, 318000, P.R. China. chenbf1221@163.com.",
    "Taizhou Central Hospital of Wenzhou Medical University, Tai Zhou, 318000, P.R. China. chenbf1221@163.com.",
    "Taizhou Central Hospital (Taizhou University Hospital), Tai Zhou, 318000, P.R. China. liukaiTZ@tzc.edu.cn.",
    "Taizhou Central Hospital of Wenzhou Medical University, Tai Zhou, 318000, P.R. China. liukaiTZ@tzc.edu.cn.",
    "Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms, School of Life Sciences, Zhejiang International Science and Technology Cooperation Base for Biomass Resources Development and Utilization, Taizhou, 318000, Zhejiang Province, P.R. China. liukaiTZ@tzc.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Chumeng Zhu"
    },
    {
      "affs": [
        2
      ],
      "name": "Dong Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Minjie Jiang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Haitao Huang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Haisheng Zhang"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Baofu Chen"
    },
    {
      "affs": [
        6,
        7,
        8
      ],
      "name": "Kai Liu",
      "orcid": "0000-0001-6039-2681"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ajvx21psrq9t6.bib",
  "cited_by": 0,
  "doi": "10.1186/s13019-026-04508-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13753314",
  "id": "ajvx21psrq9t6",
  "issns": [
    "1749-8090"
  ],
  "landing_url": "https://europepmc.org/article/MED/43010027",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|MicroRNA in disease regulation"
    ]
  ],
  "openalex": "W7202244733",
  "pdf_url": "https://europepmc.org/articles/PMC13753314?pdf=render",
  "pmcid": "PMC13753314",
  "pmid": "43010027",
  "published": "2026-08-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ajvx21psrq9t6.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:22:43Z",
      "native_id": "MED:43010027",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43010027"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|MicroRNA in disease regulation",
      "subfield": "oncology"
    }
  ],
  "title": "miR-511 suppresses non-small cell lung cancer by targeting EREG.",
  "title_text": "miR-511 suppresses non-small cell lung cancer by targeting EREG.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T03:20:45Z",
  "url": "https://research.draconitic.com/paper/ajvx21psrq9t6",
  "venue": "Journal of cardiothoracic surgery",
  "versions": []
}