{
  "abstract": "The aim of this study was to develop a 3D multifunctional porous composite based on marine polymers, fish collagen (COL) extracted from Dicentrarchus labrax skin and sulfated polysaccharides (SP) extracted from Cladophora vagabunda seaweed, supplemented with wormwood ( Artemisia absinthium ) emulsion (WE) for improving the healing of chronic wounds. Characterization of the submicron WE based on wormwood hydrolate showed spherical droplets by TEM, Z-average diameter of 21.31 nm and negative zeta potential determined by DLS and antimicrobial activity against Staphylococcus aureus. The 3D COL-SP-WE composite revealed porous morphology by SEM, and a gradual stress increase characteristic for a soft network capable of sustaining medium loads before deformation. The composite had good cytocompatibility in human HaCaT keratinocytes culture. In addition, supplementation of marine composite COL-SP with WE demonstrated higher decrease of the intracellular ROS production in oxidative stressed HaCaT cells, reduced level of pro-inflammatory cytokines in inflamed human THP-1-derived macrophage cells, and downregulation of matrix metalloproteinases mRNAs expression and secretion level in a HaCaT/THP-1 co-culture. However, WE supplementation did not significantly improve HaCaT migration rate in a scratch assay. All these results highlighted multifunctionality of marine composite COL-SP supplemented with WE and recommend further in vivo testing in relevant wound healing models.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Alexandra Gaspar-Pintiliescu"
    },
    {
      "name": "Ana-Maria Seciu-Grama"
    },
    {
      "name": "Andreea Plangu"
    },
    {
      "name": "Vasile Sorin Manoiu"
    },
    {
      "name": "Maria Râpă"
    },
    {
      "name": "Andrada Serafim"
    },
    {
      "name": "Justinian Tomescu"
    },
    {
      "name": "Oana Craciunescu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ak5sj5mkzdr28.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-73804-0",
  "fulltext_url": null,
  "id": "ak5sj5mkzdr28",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-73804-0",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7215045812",
  "pdf_url": "https://www.nature.com/articles/s41598-026-73804-0_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/ak5sj5mkzdr28.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.1038/s41598-026-73804-0",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-73804-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Multifunctional marine polymers composite supplemented with Artemisia absinthium emulsion for improving chronic wound healing: an in vitro study",
  "title_text": "Multifunctional marine polymers composite supplemented with Artemisia absinthium emulsion for improving chronic wound healing: an in vitro study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/ak5sj5mkzdr28",
  "venue": "Scientific Reports",
  "versions": []
}