{
  "abstract": "Obesity is a major risk factor for chronic kidney disease. Time-restricted feeding (TRF) shows promise to reduce kidney inflammation in chronic kidney disease. We hypothesized that TRF blunts kidney fibrosis in obese mice by mitigating T cell inflammation. We used a diet-induced obese mouse model fed a high-fat diet (DIO; 45% fat) ad libitum for 18 weeks followed by 2 weeks of TRF or ad libitum high-fat feeding. We found that TRF reversed kidney fibrosis as well as reduced kidney CD8+ T cells in DIO mice. Our study also reveals that DIO mice had increased kidney CD8+ T cell infiltration from the small intestine that was blunted with TRF. Furthermore, anti-CD8 intervention in DIO showed reduced kidney fibrosis and damage compared with anti-IgG–treated DIO mice. Single-cell RNA-seq data reveal that DIO increased, while TRF reduced, the frequency of a specific cluster of CD8+ T cells that featured high expression of exhaustion/activation genes. Spatial analyses showed DIO mice had significant infiltration of PD-1+CD8+ T cells near CD31+ endothelial cells that was diminished by TRF. In conclusion, this study shows that TRF reversed kidney fibrosis through reducing CD8+ T cell infiltration in obese mice.",
  "abstract_shown": true,
  "affiliations": [
    "Cardio-Renal Physiology & Medicine",
    "Division of Nephrology, Department of Medicine",
    "Division of Clinical Immunology & Rheumatology, Department of Medicine",
    "Department of Radiology",
    "Department of Neurology, and",
    "Department of Hematology and Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Claudia J. Edell"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "John D. Erickson"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaofen Liu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Savannah C. Walker"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jackson Colson"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Michael Heim"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pranav Nagila"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kyle H. Moore",
      "orcid": "0000-0002-8028-8205"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Keri M. Kemp"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kelly Hyndman",
      "orcid": "0000-0002-8465-2588"
    },
    {
      "affs": [
        2
      ],
      "name": "Selene Meza-Perez",
      "orcid": "0000-0001-7881-6964"
    },
    {
      "affs": [
        2
      ],
      "name": "Troy D. Randall"
    },
    {
      "affs": [
        3
      ],
      "name": "Annye P. Bennett"
    },
    {
      "affs": [
        3
      ],
      "name": "Anna G. Sorace"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Yu-Hua Dean Fang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "David M. Pollock"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Carmen De Miguel"
    },
    {
      "affs": [
        5
      ],
      "name": "Julienne L. Carstens"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jennifer S. Pollock"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ak7nk75h63sz9.bib",
  "cited_by": 0,
  "doi": "10.1172/jci.insight.195335",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13726415/",
  "id": "ak7nk75h63sz9",
  "issns": [
    "2379-3708"
  ],
  "landing_url": "https://doi.org/10.1172/jci.insight.195335",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2737|Dietary Effects on Health"
    ]
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  "openalex": "W7204579915",
  "pdf_url": "http://insight.jci.org/articles/view/195335/files/pdf",
  "pmcid": "PMC13726415",
  "pmid": "42664422",
  "published": "2026-08-20",
  "publisher": "American Society for Clinical Investigation",
  "ris": "https://research.draconitic.com/paper/ak7nk75h63sz9.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:22:46Z",
      "native_id": "PMC13726415",
      "source": "pmc",
      "url": "https://doi.org/10.1172/jci.insight.195335"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Dietary Effects on Health",
      "subfield": "physiology"
    }
  ],
  "title": "Time-restricted feeding reverses kidney fibrosis through reducing CD8+ T cell infiltration in obese mice",
  "title_text": "Time-restricted feeding reverses kidney fibrosis through reducing CD8+ T cell infiltration in obese mice",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:23Z",
  "url": "https://research.draconitic.com/paper/ak7nk75h63sz9",
  "venue": "JCI Insight",
  "versions": []
}