{
  "abstract": "The foveola-the central ~1{degrees} of the visual field-supports the highest-acuity spatial vision, yet localizing its cortical representation is technically demanding, particularly under anesthesia where gaze cannot be behaviorally controlled. Here we describe a hierarchical, meridian-based 7T BOLD fMRI strategy for sub-degree localization of the foveolar representation in anesthetized macaques. Drifting grating bars presented at three successively finer scales (4.5{degrees}, 1.5{degrees}, 0.5{degrees}) independently refined the vertical and horizontal meridian representations, each identified by a characteristic activation signature: bilateral convergence at the V1/V2 border for the vertical meridian, and simultaneous dorsal and ventral V2/V3 activation at the fundus of the calcarine sulcus for the horizontal. Their functional intersection defined candidate foveolar coordinates, which were refined using 0.2{degrees} spot stimuli. Surface-based rendering resolved discrete foveolar loci at the lateral end of the V1/V2, V2/V3, V3/V4 and V4/TEO borders, together delimiting the previously described 'foveolar core'. Pooling these with awake data, we place the loci in a common stereotaxic frame, yielding a first anatomical atlas of the core. Intrinsic-signal optical imaging further shows that this territory lacks the ocular-dominance and orientation columns of surrounding cortex. The approach provides a reproducible framework for locating and targeting foveolar cortex in anesthetized primates.",
  "abstract_shown": true,
  "affiliations": [
    "Nathan S. Kline Institute for Psychiatric Research"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "M. Qian"
    },
    {
      "name": "M. Chen"
    },
    {
      "name": "A. Barczak"
    },
    {
      "name": "X. Zhang"
    },
    {
      "name": "P. Li"
    },
    {
      "affs": [
        0
      ],
      "name": "A. W. Roe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/akfhpx7bnecm0.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.16.744304",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.08.16.744304v2.full",
  "id": "akfhpx7bnecm0",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.08.16.744304v2",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2805|Visual perception and processing mechanisms"
    ]
  ],
  "openalex": "W7203824695",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.08.16.744304v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/akfhpx7bnecm0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:17Z",
      "native_id": "10.64898/2026.08.16.744304",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.08.16.744304v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Precise Functional Localization of the Foveolar Representation in Anesthetized Macaque Visual Cortex",
  "title_text": "Precise Functional Localization of the Foveolar Representation in Anesthetized Macaque Visual Cortex",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:17Z",
  "url": "https://research.draconitic.com/paper/akfhpx7bnecm0",
  "venue": "bioRxiv",
  "versions": []
}