{
  "abstract": "Objectives:: To compare the risk of hypophosphatemia and associated outcomes following ferric carboxymaltose (FCM) versus ferric derisomaltose (FDI) in adults with iron deficiency anemia.\n\nMethods:: We conducted a systematic review and meta-analysis of studies identified through database searches up to November 2025. Randomized and observational studies comparing FCM and FDI were included. The primary outcome was the incidence of hypophosphatemia within 35 to 42 days after infusion. Secondary outcomes included severe and persistent hypophosphatemia, patient-reported outcomes, and economic outcomes. Data from randomized trials were quantitatively pooled using a random-effects model to calculate risk ratios (RRs) with 95% confidence intervals (CIs), whereas findings from observational and economic studies were summarized narratively.\n\nResults:: Twenty-one studies were included, comprising 3 randomized controlled trials (364 participants) and 18 observational or economic evaluation studies. In pooled randomized comparisons, FCM was associated with a higher risk of hypophosphatemia within 35 to 42 days than FDI (RR 8.37, 95% CI 5.10-13.75; P < .00001; I2 = 0%). Severe hypophosphatemia occurred in 11.3% of patients receiving FCM and was not observed with FDI. Persistent hypophosphatemia beyond 5 to 8 weeks was more frequent with FCM. Fatigue scores improved more with FDI. Economic evaluations reported greater quality-adjusted life years and lower healthcare costs with FDI.\n\nConclusion:: Ferric carboxymaltose is associated with a higher risk of hypophosphatemia compared with ferric derisomaltose. Ferric derisomaltose demonstrates a more favorable safety profile and consistent economic findings.",
  "abstract_shown": true,
  "affiliations": [
    "School of Medicine, Xiamen University, Xiamen, China",
    "ESIC Medical College and Hospital, Sanathnagar, Hyderabad, India",
    "Flinders University, Adelaide, Australia",
    "DOW University of Health Sciences, Karachi, Pakistan",
    "Davao Medical School Foundation, Inc., Davao City, Philippines",
    "Royal College of Surgeons in Ireland, Dublin, Ireland",
    "Bahria University Health Sciences Campus, Karachi, Pakistan",
    "St George’s University Hospitals NHS Foundation Trust, London, UK",
    "College of Medical Sciences, Bharatpur, Nepal"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Vidhita Dangre",
      "orcid": "0000-0002-8746-8647"
    },
    {
      "affs": [
        1
      ],
      "name": "Mohd Rafiuddin",
      "orcid": "0009-0005-6335-5217"
    },
    {
      "affs": [
        2
      ],
      "name": "Krithika Sriram",
      "orcid": "0000-0003-1438-2938"
    },
    {
      "affs": [
        3
      ],
      "name": "Iqra Aslam Siddiqui",
      "orcid": "0009-0002-2060-9545"
    },
    {
      "affs": [
        3
      ],
      "name": "Hadia Fahim",
      "orcid": "0009-0009-9275-7986"
    },
    {
      "affs": [
        4
      ],
      "name": "Shanthakumar Sakthivel Murugan",
      "orcid": "0009-0006-2905-6341"
    },
    {
      "affs": [
        5
      ],
      "name": "Federica Copeta",
      "orcid": "0009-0004-9432-1303"
    },
    {
      "affs": [
        6
      ],
      "name": "Noor Ul Ain Fatima",
      "orcid": "0009-0002-4530-537X"
    },
    {
      "affs": [
        7
      ],
      "name": "Belinda Eze",
      "orcid": "0009-0001-0848-1158"
    },
    {
      "affs": [
        8
      ],
      "name": "Swostika Pokhrel",
      "orcid": "0009-0000-5258-5627"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aktjdw2ps6gtx.bib",
  "cited_by": 0,
  "doi": "10.1177/00185787261485528",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696579/",
  "id": "aktjdw2ps6gtx",
  "issns": [
    "0018-5787",
    "1945-1253"
  ],
  "landing_url": "https://doi.org/10.1177/00185787261485528",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
    ],
    [
      "openalex",
      "2720|Iron Metabolism and Disorders"
    ]
  ],
  "openalex": "W7223565350",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13696579/pdf/?tool=EBI",
  "pmcid": "PMC13696579",
  "pmid": "42936098",
  "published": "2026-10-24",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/aktjdw2ps6gtx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:54Z",
      "native_id": "PMC13696579",
      "source": "pmc",
      "url": "https://doi.org/10.1177/00185787261485528"
    },
    {
      "first_seen": "2026-10-30T12:21:25Z",
      "native_id": "PMC:PMC13696579",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13696579"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Iron Metabolism and Disorders",
      "subfield": "general"
    }
  ],
  "title": "Time Course and Comparative Risk of Hypophosphatemia After Ferric Carboxymaltose versus Ferric Derisomaltose: A Systematic Review, Meta-analysis, and Clinical Cost Considerations",
  "title_text": "Time Course and Comparative Risk of Hypophosphatemia After Ferric Carboxymaltose versus Ferric Derisomaltose: A Systematic Review, Meta-analysis, and Clinical Cost Considerations",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:53Z",
  "url": "https://research.draconitic.com/paper/aktjdw2ps6gtx",
  "venue": "Hospital Pharmacy",
  "versions": []
}