{
  "abstract": "The brain continuously reconfigures through a repertoire of transient states and transitions. However, most studies on neuropsychiatric disorders still relate symptoms to static or time-averaged measures of brain organization. Here, we review emerging evidence that clinically relevant information is also contained in the brain dynamical repertoire, including the states accessible to an individual, their occupancy, persistence, and transition structure. Across psychiatric, neurodevelopmental, neurological, and neurodegenerative disorders, alterations in these dynamical features have been associated with symptom severity, cognitive impairment, functional outcome, and treatment response. Importantly, emerging longitudinal studies further suggest that brain dynamics can change with clinical state and, in some cases, provide information about subsequent symptom trajectories. We argue that these findings motivate a shift from viewing brain dynamics primarily as cross-sectional correlates of diagnostic categories toward examining how changes in an individual's dynamical repertoire relate to the evolution of symptoms over time.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Damien Depannemaecker"
    },
    {
      "name": "Florencia Altschuler"
    },
    {
      "name": "Hélène Soydemir"
    },
    {
      "name": "Gabriele Casagrande"
    },
    {
      "name": "Cecilia Gonzalez Campo"
    },
    {
      "name": "Pierpaolo Sorrentino"
    },
    {
      "name": "Antoine Lefrère"
    },
    {
      "name": "Christophe Gauld"
    },
    {
      "name": "VIktor Jirsa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/am2j1h380r3qx.bib",
  "cited_by": 0,
  "doi": "10.31234/osf.io/4738x_v1",
  "fulltext_url": null,
  "id": "am2j1h380r3qx",
  "issns": [],
  "landing_url": "https://osf.io/preprints/psyarxiv/4738x_v1/",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "bepress",
      "Neuroscience"
    ],
    [
      "bepress",
      "Psychiatry"
    ],
    [
      "openalex",
      "2805|Functional Brain Connectivity Studies"
    ]
  ],
  "openalex": "W7212295203",
  "pdf_url": "https://osf.io/4738x/download",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/am2j1h380r3qx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:25:13Z",
      "native_id": "4738x",
      "source": "osf",
      "url": "https://osf.io/preprints/psyarxiv/4738x_v1/"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "bepress:Neuroscience",
      "subfield": "neuroscience"
    },
    {
      "field": "medicine",
      "origin": "bepress:Psychiatry",
      "subfield": "psychiatry"
    }
  ],
  "title": "The Brain Dynamical Repertoire and the Evolution of Clinical Symptoms",
  "title_text": "The Brain Dynamical Repertoire and the Evolution of Clinical Symptoms",
  "type": "preprint",
  "updated_at": "2026-10-30T12:25:13Z",
  "url": "https://research.draconitic.com/paper/am2j1h380r3qx",
  "venue": "PsyArXiv",
  "versions": []
}