{
  "abstract": "Introduction Anti-glomerular basement membrane (anti-GBM) disease is a rare vasculitis that is characterized by a poor renal prognosis. Despite the high predictive accuracy of the improved ANCA Kidney Risk Score (AKRiS) in ANCA-associated vasculitis, its prognostic value in anti-GBM disease remains to be established. Methods In this multicenter retrospective study, 163 biopsy-proven anti-GBM patients were included. AKRiS was calculated at diagnosis, stratifying patients into low-, moderate-, high-, and very high-risk groups. The Fine-Gray model was used for the analysis of 36-month kidney failure, with the predictive performance assessed via Harrell's C-index. Results The median AKRiS was 18 [11–21], with 69% of patients classified as high or very high-risk. The 36-month cumulative incidence of kidney failure was significantly higher in the high- (92% [95%CI: 82–97]) and very high-risk (98% [95%CI: 86–100]) groups, when compared to the low-risk (40% [95%CI: 19–61]; p<0.0001). In the multivariable analysis, AKRiS was independently associated with a poor renal prognosis (sHR 2.51 and 2.82 for the high- and very high-risk groups vs. low-risk, respectively). The model combining oligoanuria and AKRiS improved the predictive performance of AKRiS alone (C-index 0.90 [95%CI: 0.85–0.94] vs 0.85 [95%CI: 0.80–0.91]; p=0.02). Despite higher AKRiS scores, double-positive patients had similar 36-month kidney failure compared to single-positive patients, reflecting their divergent pathophysiological and therapeutic responsiveness. Conclusion AKRiS is associated with renal risk in anti-GBM disease, irrespective of ANCA status. Its predictive performance further improves when combined with oligoanuria, supporting the development of pragmatic prognostic models for anti-GBM disease.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "name": "Pauline Caillard"
    },
    {
      "name": "Cécile Vigneau"
    },
    {
      "name": "Jean-Michel Halimi"
    },
    {
      "name": "Marc Hazzan"
    },
    {
      "name": "Eric Thervet"
    },
    {
      "name": "Morgane Heitz"
    },
    {
      "name": "Laurent Juillard"
    },
    {
      "name": "Vincent Audard"
    },
    {
      "name": "Marion Rabant"
    },
    {
      "name": "Alexandre Hertig"
    },
    {
      "name": "Benoit Brilland"
    },
    {
      "name": "Vincent Vuiblet"
    },
    {
      "name": "Dominique Guerrot"
    },
    {
      "name": "Mathilde Tamain"
    },
    {
      "name": "Marie Essig"
    },
    {
      "name": "Thierry Lobbedez"
    },
    {
      "name": "Thomas Quemeneur"
    },
    {
      "name": "Mathieu Legendre"
    },
    {
      "name": "Alexandre Ganea"
    },
    {
      "name": "Marie-Noëlle Peraldi"
    },
    {
      "name": "François Vrtovsnik"
    },
    {
      "name": "Maïté Daroux"
    },
    {
      "name": "Gabriel Choukroun"
    },
    {
      "name": "Dimitri Titeca-Beauport"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/amn0gqj09kwxr.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ekir.2026.107130",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2468024926033620",
  "id": "amn0gqj09kwxr",
  "issns": [
    "2468-0249"
  ],
  "landing_url": "https://u-picardie.hal.science/hal-05795068v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
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    [
      "lcc",
      "RC870-923"
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      "openalex",
      "2740|Vasculitis and related conditions"
    ]
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  "openalex": "W7220733677",
  "pdf_url": "https://www.kireports.org/article/S2468-0249(26)03362-0/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-12",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/amn0gqj09kwxr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:54Z",
      "native_id": "hal-05795068",
      "source": "hal",
      "url": "https://u-picardie.hal.science/hal-05795068v1"
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    {
      "first_seen": "2026-11-05T14:21:20Z",
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  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
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    {
      "field": "medicine",
      "origin": "hal:1.sdv.mhep",
      "subfield": "general"
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  ],
  "title": "Association of the ANCA Kidney Risk Score with kidney failure in anti-GBM disease",
  "title_text": "Association of the ANCA Kidney Risk Score with kidney failure in anti-GBM disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T14:20:33Z",
  "url": "https://research.draconitic.com/paper/amn0gqj09kwxr",
  "venue": "Kidney International Reports",
  "versions": []
}