{
  "abstract": "Objective: Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare acquired clonal abnormality that makes hematopoietic cells highly vulnerable to complement-mediated destruction. Fatigue is one of the most commonly reported unresolved symptoms by patients with PNH. In this study, the fatigue status of PNH patients receiving eculizumab treatment and the factors affecting fatigue were evaluated using a quality-of-life questionnaire. Materials and Methods: The study included 18 centers from Türkiye. The quality of life of PNH patients receiving eculizumab treatment was assessed through face-to-face surveys using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale. Results: A total of 104 PNH patients treated with eculizumab were included in the study, of whom 51 (49%) were female and 53 (51%) were male. The mean (±SD) age of the patients was 48.04 (±16.16) years at the time of the survey. The mean (±SD) FACIT-Fatigue score was 32.63 (±11.79). A total of 39 (37.5%) patients had a fatigue score of 30 or below, which was defined as severe fatigue. Patients with severe fatigue had lower hemoglobin levels both at diagnosis and at the time of the survey [8.05 g/dL vs. 9.15 g/dL (p = 0.017) and 10.09 g/dL vs. 11.38 g/dL (p = 0.006), respectively]. The mean (±SD) duration of additional medication use was longer in the severe fatigue group compared to patients with a fatigue score >30 [97.92(±51.98) months vs. 75.94 (±50.55) months, p = 0.039]. In the multivariate analysis, the independent variables ‘female gender,’ ‘presence of comorbidities,’ ‘duration of additional medication,’ and ‘initial hemoglobin level’ were statistically significantly associated with severe fatigue. The female gender increased the likelihood of severe fatigue by 3.3 times, while the presence of comorbidities increased it by 7.1 times. Conclusion: In this study, which evaluated the fatigue status of PNH patients at various stages of eculizumab treatment in a real-life setting, more than one-third of the patients reported severe fatigue. Female patients experienced severe fatigue more than male patients, and anemia was not the sole factor contributing to severe fatigue in PNH patients. Comorbidities and medications related to these conditions also played a significant role in their quality of life.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology, School of Medicine, TOBB Economics and Technology University, Ankara, Türkiye",
    "Department of Hematology, School of Medicine, Ege University, İzmir, Türkiye",
    "Department of Hematology, School of Medicine, Çukurova University, Adana, Türkiye",
    "Department of Hematology, School of Medicine, Ankara University, Ankara, Türkiye",
    "Department of Hematology, School of Medicine, Eskişehir Osmangazi University, Eskişehir, Türkiye",
    "Department of Hematology, School of Medicine, Marmara University, İstanbul, Türkiye",
    "Department of Hematology, School of Medicine, Erciyes University, Kayseri, Türkiye",
    "Department of Hematology, School of Medicine, Kocaeli University, İzmit, Türkiye",
    "Department of Hematology, School of Medicine, Gaziantep University, Gaziantep, Türkiye",
    "Department of Hematology, School of Medicine, Dokuz Eylül University, İzmir, Türkiye",
    "Department of Hematology, School of Medicine, Pamukkale University, Denizli, Türkiye",
    "Department of Hematology, School of Medicine, Karadeniz Teknik University, Trabzon, Türkiye",
    "Department of Hematology, School of Medicine, Akdeniz University, Antalya, Türkiye",
    "Department of Hematology, School of Medicine, Van Yüzüncü Yıl University, Van, Türkiye",
    "Department of Hematology, Bilkent City Hospital, Ankara, Türkiye",
    "Department of Hematology, Çam and Sakura City Hospital, İstanbul, Türkiye",
    "Department of Hematology, School of Medicine, Mersin University, Mersin, Türkiye",
    "Department of Hematology, School of Medicine, Sanko University, Gaziantep, Türkiye",
    "Department of Hematology, Çapa School of Medicine, İstanbul University, İstanbul, Türkiye",
    "Department of Hematology, School of Medicine, Lokman Hekim University, Ankara, Türkiye"
  ],
  "article_type": "Research Article",
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  "author_total": 34,
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    {
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        0
      ],
      "name": "Zehra Narlı Özdemir"
    },
    {
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        1
      ],
      "name": "Fatma Keklik Karadağ"
    },
    {
      "affs": [
        2
      ],
      "name": "Nuray Gül Acar"
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    {
      "affs": [
        3
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      "name": "Merve Aydoğan"
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    {
      "affs": [
        4
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      "name": "Filiz Yavaşoğlu"
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    {
      "affs": [
        5
      ],
      "name": "Fatma Temiz"
    },
    {
      "affs": [
        6
      ],
      "name": "Ajda Güneş"
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    {
      "affs": [
        7
      ],
      "name": "Gülşah Akyol"
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    {
      "affs": [
        8
      ],
      "name": "Haşim Atakan Erol"
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    {
      "affs": [
        9
      ],
      "name": "Özgür Mehtap"
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    {
      "affs": [
        10
      ],
      "name": "Vahap Okan"
    },
    {
      "affs": [
        11
      ],
      "name": "Merve Kakçı"
    },
    {
      "affs": [
        12
      ],
      "name": "İsmail Can Kendir"
    },
    {
      "affs": [
        13
      ],
      "name": "Turhan Köksal"
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    {
      "affs": [
        14
      ],
      "name": "Utku Iltar"
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    {
      "affs": [
        15
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      "name": "Ramazan Esen"
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    {
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        16
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      "name": "Gülten Korkmaz"
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      "name": "Mesut Ayer"
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    {
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        18
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      "name": "Esin Oğuz"
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    {
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        19
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      "name": "Ozan Salim"
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    {
      "name": "Anıl Tombak"
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    {
      "name": "Mehmet Sönmez"
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    {
      "name": "Nil Güler"
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    {
      "name": "Mehmet Yilmaz"
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    {
      "name": "Mehmet Ali Özcan"
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    {
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    {
      "name": "Tülin Tuğlular"
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    {
      "name": "Selami Koçak Toprak"
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    {
      "name": "Birol Güvenç"
    },
    {
      "name": "Mustafa Nuri Yenerel"
    },
    {
      "name": "Osman İlhan"
    },
    {
      "name": "Güray Saydam"
    },
    {
      "name": "Fahri Şahin"
    }
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  "bibtex": "https://research.draconitic.com/paper/amtg4vzkqsjbv.bib",
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  "published": "2026-09-11",
  "publisher": "Public Library of Science",
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  "title": "FACIT-fatigue score and treatment quality assessment for paroxysmal nocturnal hemoglobinuria patients treated with Eculizumab in Türkiye",
  "title_text": "FACIT-fatigue score and treatment quality assessment for paroxysmal nocturnal hemoglobinuria patients treated with Eculizumab in Türkiye",
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