{
  "abstract": "Treating chronic neuropathic pain is challenging due to its complex pathophysiology. Persistent changes in the somatosensory system prolong heightened states of stimulus-evoked and spontaneous pain. Nociceptor dorsal root ganglion (DRG) neurons are key contributors to neuropathic pain due to pathological plasticity following injury, leading to spontaneous ectopic and stimulus-evoked firing. Preclinical strategies to inhibit Nav1.8, a nociceptor-specific voltage-gated sodium channel, are successful in reducing neuropathic pain but have yet to produce similar results in clinical settings. Here, we evaluate the pharmacotherapeutic potential of the Nav1.8/Ank3 interaction in neuropathic pain, utilizing electrophysiology, biochemistry, and proteomic approaches. We report that Nav1.8/Ank3 interactions are necessary for maintaining pathological nociceptor hyperexcitability in neuroma pain and that inhibition of this interaction with a short lipidated peptide (SLiP) is sufficient to alleviate neuropathic pain-like behaviors in mice. This work highlights the value of reevaluating targets for pharmacological intervention to produce analgesia specific to pathological states.",
  "abstract_shown": true,
  "affiliations": [
    "F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA, USA",
    "Department of Neurobiology, Harvard Medical School, Boston, MA, USA",
    "Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA",
    "Department of Neurology, Yale School of Medicine, New Haven, CT, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Rasheen Powell"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiangsunze Zeng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Bruna Lenfers Turnes"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hyoung Woo Kim"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Veselina Petrova"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Selwyn S. Jayakar"
    },
    {
      "affs": [
        0
      ],
      "name": "Emily Shea"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Keunjung Heo"
    },
    {
      "affs": [
        0
      ],
      "name": "Emma Cropper"
    },
    {
      "affs": [
        0
      ],
      "name": "Maryam Arab"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Georgios Kimourtzis"
    },
    {
      "affs": [
        2
      ],
      "name": "Juan A. Oses-Prieto"
    },
    {
      "affs": [
        2
      ],
      "name": "Alma L. Burlingame"
    },
    {
      "affs": [
        3
      ],
      "name": "Stephen G. Waxman"
    },
    {
      "affs": [
        3
      ],
      "name": "Sulayman D. Dib-Hajj"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Clifford J. Woolf"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/amw0qyxzjq3ep.bib",
  "cited_by": 1,
  "doi": "10.1016/j.xcrm.2026.103090",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710374/",
  "id": "amw0qyxzjq3ep",
  "issns": [
    "2666-3791"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103090",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2737|Pain Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7220698799",
  "pdf_url": null,
  "pmcid": "PMC13710374",
  "pmid": "42838058",
  "published": "2026-10-06",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/amw0qyxzjq3ep.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:21Z",
      "native_id": "PMC13710374",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xcrm.2026.103090"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Pain Mechanisms and Treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Disruption of the Nav1.8/Ankyrin-3 interaction in nociceptors reduces pathological pain-like behaviors in mice",
  "title_text": "Disruption of the Nav1.8/Ankyrin-3 interaction in nociceptors reduces pathological pain-like behaviors in mice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:21Z",
  "url": "https://research.draconitic.com/paper/amw0qyxzjq3ep",
  "venue": "Cell Reports Medicine",
  "versions": []
}