{
  "abstract": "The erector spinae plane block (ESPB) is a promising regional technique for cardiac surgery. We evaluated the efficacy of ESPB regarding analgesia and in-hospital outcomes in patients undergoing coronary artery bypass grafting (CABG). We conducted a systematic review and meta-analysis comparing ESPB versus control in adults undergoing CABG (CRD42025645045). Primary outcomes were opioid consumption (24 h/48 h) and pain intensity. Secondary outcomes included extubation time and intensive care unit (ICU) length of stay. Data were pooled using random-effects models. Meta-regression and trial sequential analysis (TSA) were used to assess sources of heterogeneity and robustness, respectively, while the Grading of Recommendations, Assessment, Development, and Evaluations framework provided the certainty of the evidence for each outcome. Twelve studies (704 patients) were analyzed. ESPB significantly reduced the morphine milligram equivalent consumption at 24 h (mean difference (MD) –19.05 mg; 95% confidence interval (CI) [–22.50 to –15.61]; P < 0.001; high certainty) and 48 h (MD –19.42 mg; 95% CI [–28.75 to –10.09]; P < 0.001; moderate certainty). Pain scores, by the Numerical Rating Scale, were lower within 12 h (MD –0.93; P < 0.001; moderate certainty) and at 24 h (MD –0.58; P = 0.016; low certainty). ESPB shortened extubation time (MD –2.50 h; high certainty) and ICU stay (MD –12.55 h; moderate certainty). TSA confirmed robust evidence for opioid reduction, early pain relief, and extubation benefits. ESPB provides effective early analgesia, reduces perioperative opioid requirements, and accelerates recovery in CABG, representing a fundamental complement to conventional isolated intravenous analgesia. Future research should investigate continuous techniques.",
  "abstract_shown": true,
  "affiliations": [
    "Federal University of Bahia, Salvador, Brazil",
    "Botucatu School of Medicine, Paulista State University, Botucatu, Brazil"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "João Paulo Aureliano de Carvalho"
    },
    {
      "affs": [
        0
      ],
      "name": "Helen dos Reis Requião"
    },
    {
      "affs": [
        1
      ],
      "name": "Rodrigo Mascarenhas Vieira"
    },
    {
      "affs": [
        0
      ],
      "name": "Pablo de Sousa Ferreira"
    },
    {
      "affs": [
        0
      ],
      "name": "Elias Batista da Silva Neto"
    },
    {
      "affs": [
        0
      ],
      "name": "Liana Maria Tôrres de Araújo Azi"
    },
    {
      "affs": [
        1
      ],
      "name": "Norma Sueli Pinheiro Módolo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rodrigo Leal Alves"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/an868p6xk1eqr.bib",
  "cited_by": 1,
  "doi": "10.4103/aca.aca_17_26",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13743097/",
  "id": "an868p6xk1eqr",
  "issns": [
    "0971-9784",
    "0974-5181"
  ],
  "landing_url": "https://doi.org/10.4103/aca.aca_17_26",
  "language": "en",
  "licence": "CC-BY-NC-SA-4.0",
  "licence_label": "CC BY-NC-SA 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "2703|Anesthesia and Pain Management"
    ]
  ],
  "openalex": "W7221569582",
  "pdf_url": null,
  "pmcid": "PMC13743097",
  "pmid": "42862662",
  "published": "2026-10-12",
  "publisher": "Wolters Kluwer -- Medknow Publications",
  "ris": "https://research.draconitic.com/paper/an868p6xk1eqr.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:23:49Z",
      "native_id": "PMC13743097",
      "source": "pmc",
      "url": "https://doi.org/10.4103/aca.aca_17_26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2703|Anesthesia and Pain Management",
      "subfield": "surgery"
    }
  ],
  "title": "Impact of Erector Spinae Block on Postoperative Analgesia and Hospital Recovery in Coronary Artery Bypass Surgery: A Systematic Review with Meta-analysis, Meta-Regression, and Sequential Trial Analysis",
  "title_text": "Impact of Erector Spinae Block on Postoperative Analgesia and Hospital Recovery in Coronary Artery Bypass Surgery: A Systematic Review with Meta-analysis, Meta-Regression, and Sequential Trial Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:23:49Z",
  "url": "https://research.draconitic.com/paper/an868p6xk1eqr",
  "venue": "Annals of Cardiac Anaesthesia",
  "versions": []
}