{
  "abstract": "Complement component 1q (C1q), the initiator of the classical complement cascade, mediates synaptic elimination in development and disease, yet the triggers for its deposition on synapses remain unclear. Using in vivo chemogenetics, we demonstrate that neuronal hyperactivity induces region-specific, C1q-dependent synapse loss in the adult hippocampus. Suppressing perforant pathway hyperactivity in a mouse model of Alzheimer's disease reduced local amyloid-β amounts and C1q deposition and partially rescued synapse loss. Combining spatial transcriptomics, live cell tracking, and super-resolution microscopy, we identified association of antibody-secreting B-lineage cells in the adult hippocampus with activity-dependent, C1q-mediated synapse loss under physiological conditions. Together, these findings link neuronal hyperactivity to C1q-mediated synapse loss in the adult brain and implicate immunoglobulins as players in this process.",
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  "affiliations": [
    "UK Dementia Research Institute, Institute of Neurology, University College London, London, UK",
    "University College London",
    "Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK",
    "A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland",
    "University of Cambridge",
    "Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK",
    "Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK",
    "Katholieke Universiteit Leuven",
    "The Francis Crick Institute, London, UK",
    "Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven, Belgium",
    "VIB-KU Leuven Center for Neuroscience, Leuven, Belgium",
    "Brain and Systems Immunology Laboratory, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium",
    "Laboratory of Myeloid Cell Immunology, VIB Center for Inflammation Research, Brussels, Belgium",
    "Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK",
    "Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK"
  ],
  "article_type": null,
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  "author_total": 33,
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        1
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      "name": "Gerard Crowley",
      "orcid": "0000-0003-0436-1332"
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      "name": "Minjung Kim",
      "orcid": "0009-0009-8026-4471"
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      "name": "Nathanael O’Neill",
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      "name": "Emir Turkes",
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      "name": "Fateme Ghasemi"
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      "name": "Luca Giudice",
      "orcid": "0000-0003-0593-4067"
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      "name": "Sebastiaan De Schepper",
      "orcid": "0000-0003-0640-2417"
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        1
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      "name": "Benjy J.Y. Tan",
      "orcid": "0000-0002-8275-7378"
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        1
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      "name": "Benito Maffei",
      "orcid": "0009-0000-9983-9209"
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        1
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      "name": "Laís S. S. Ferreira",
      "orcid": "0000-0002-0152-459X"
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      "name": "Julie Rebejac",
      "orcid": "0000-0002-3822-6836"
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      "name": "Javier Rueda‐Carrasco",
      "orcid": "0000-0002-9280-6612"
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        4
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      "name": "Margarita Toneva",
      "orcid": "0000-0001-7602-586X"
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        7
      ],
      "name": "John Christian Fajardo",
      "orcid": "0009-0006-3421-3516"
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        1
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      "name": "Judy Z. Ge"
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    {
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      "name": "Zhengyue Grace Yang",
      "orcid": "0000-0002-5005-0028"
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    {
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        1
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      "name": "Paula Korhonen",
      "orcid": "0000-0001-5856-1474"
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        1
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      "name": "Phillip Muckett"
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      "name": "Damaris Bennett"
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      "name": "Camille Paoletti"
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    {
      "affs": [
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      "name": "Tammie Tao Min Sow"
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      "name": "David A Posner",
      "orcid": "0000-0001-9644-4674"
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      "name": "Annerieke S. R. Sierksma",
      "orcid": "0000-0001-9233-972X"
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      "name": "Dimitra Sokolova",
      "orcid": "0000-0001-8925-5154"
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    {
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      ],
      "name": "Viktoras Konstantellos",
      "orcid": "0009-0004-9990-1075"
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      "name": "Leen Ali",
      "orcid": "0000-0002-6782-2338"
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      "name": "Kiavash Movahedi",
      "orcid": "0000-0002-0826-4399"
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      "name": "Andrew F. MacAskill",
      "orcid": "0000-0002-0196-3779"
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      "name": "Victor L. J. Tybulewicz",
      "orcid": "0000-0003-2439-0798"
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      "name": "Tarja Malm",
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      "orcid": "0000-0002-3963-9296"
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      "name": "Menna Ruth Clatworthy",
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      "name": "Soyon Youngae Hong",
      "orcid": "0000-0002-5744-4871"
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  "bibtex": "https://research.draconitic.com/paper/an8nmgcadrmn5.bib",
  "cited_by": 14,
  "doi": "10.1126/science.adv1219",
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  "id": "an8nmgcadrmn5",
  "issns": [
    "0036-8075",
    "0193-4511",
    "1095-9203"
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  "landing_url": "https://doi.org/10.1126/science.adv1219",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
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  "pmcid": null,
  "pmid": "42424464",
  "published": "2026-07-09",
  "publisher": "American Association for the Advancement of Science",
  "ris": "https://research.draconitic.com/paper/an8nmgcadrmn5.ris",
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  "title": "C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain",
  "title_text": "C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T13:20:55Z",
  "url": "https://research.draconitic.com/paper/an8nmgcadrmn5",
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