{
  "abstract": "A novel, eco-friendly one-pot synthesis of oxamide was developed using nontoxic starting materials, offering a safer alternative to traditional methods. The procedure yields a highly pure oxamide precipitate within 2 days. By optimizing key reaction parameters including temperature, ascorbic acid/ammonia ratio, and ammonia concentration, the precipitation yield can be finely tuned. The resulting oxamide was comprehensively characterized by X-ray diffraction (XRD), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX), Fourier transform infrared spectroscopy (FT-IR), and one-dimensional/two-dimensional (1D/2D) nuclear magnetic resonance (NMR). Concurrently, the liquid supernatant was analyzed by EDX, NMR, and mass spectrometry (MS), revealing the bioactive metabolite l-threonic acid as the sole major byproduct, with no other toxic compounds detected.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Letter and Philosophy, University of Cassino and Southern Lazio, Loc. Folcara, 03043 Cassino, FR, Italy.",
    "Laboratory of Materials, Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, via Gaetano di Biasio 43, 03043 Cassino, FR, Italy.",
    "Institute of Environmental Geology and Geoengineering, National Research Council, Area della Ricerca di Roma 1, Via Salaria Km 29.300, C.P. 10, Monterotondo Stazione, 00015 Montelibretti, Rome, Italy.",
    "Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Naples, Italy.",
    "Department of Engineering, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.",
    "Department of Chemistry, Istituto Zooprofilattico Sperimentale del Mezzogiorno, via Salute 2, 80055 Portici, NA, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Maria Cristina Mascolo",
      "orcid": "0000-0002-6183-6659"
    },
    {
      "affs": [
        3
      ],
      "name": "Laura Grauso"
    },
    {
      "affs": [
        4
      ],
      "name": "Nicola Di Costanzo",
      "orcid": "0000-0003-3440-7151"
    },
    {
      "affs": [
        5
      ],
      "name": "Pasquale Gallo"
    },
    {
      "affs": [
        3
      ],
      "name": "Virginia Lanzotti"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/anes4n5b9e7sd.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c05095",
  "fulltext_url": "https://europepmc.org/articles/PMC13712478",
  "id": "anes4n5b9e7sd",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948466",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1605|Chemical Synthesis and Reactions"
    ]
  ],
  "openalex": "W7214399011",
  "pdf_url": "https://europepmc.org/articles/PMC13712478?pdf=render",
  "pmcid": "PMC13712478",
  "pmid": "42948466",
  "published": "2026-09-25",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/anes4n5b9e7sd.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:35Z",
      "native_id": "MED:42948466",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948466"
    },
    {
      "first_seen": "2026-10-31T12:23:02Z",
      "native_id": "PMC13712478",
      "source": "pmc",
      "url": "https://doi.org/10.1021/acsomega.6c05095"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Chemical Synthesis and Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Eco-friendly One-Pot Synthesis of Oxamide.",
  "title_text": "Eco-friendly One-Pot Synthesis of Oxamide.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:23:02Z",
  "url": "https://research.draconitic.com/paper/anes4n5b9e7sd",
  "venue": "ACS omega",
  "versions": []
}