{
  "abstract": "To compare the clinicopathological features, treatment response, and renal outcomes of patients with IgA nephropathy (IgAN) with κ-dominant, κ–λ co-deposition, or λ-dominant light-chain deposition. This retrospective, single-centre cohort study included 105 patients with primary IgAN who underwent their first native-kidney biopsy. Twenty-one patients with κ-dominant deposition were matched to 42 patients with κ–λ co-deposition and 42 patients with λ-dominant deposition based on age, sex, 24-hour urinary protein excretion, and baseline serum creatinine. The final matching ratio was 1:2:2. The primary renal endpoint was a sustained ≥30% increase in serum creatinine from baseline. During a median follow-up of 25 months (IQR, 18–36), 21 patients reached the renal endpoint. Time to treatment response did not differ significantly among the three groups (log-rank p = 0.0707). However, renal progression-free survival differed significantly among the light-chain deposition groups (log-rank p = 0.0046). After adjustment for sex, age, 24-hour urinary protein excretion, and baseline eGFR, a higher κ deposition ratio remained associated with a lower hazard of renal progression (HR [per 1-percentage-point increase] 0.96; 95% CI: 0.94–0.99; p = 0.011). A higher κ light-chain deposition ratio was associated with a lower risk of renal progression in IgAN. κ predominance may be a pathological marker of a distinct and possibly less aggressive immune-complex deposition pattern.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine (Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University), Hangzhou, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiang Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenhui He"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyu Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Anni Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuanli Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xue Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jin Yu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/anfvj9gjdwnm2.bib",
  "cited_by": 0,
  "doi": "10.1080/0886022x.2026.2745216",
  "fulltext_url": "https://www.tandfonline.com/doi/10.1080/0886022X.2026.2745216",
  "id": "anfvj9gjdwnm2",
  "issns": [
    "1525-6049",
    "0886-022X"
  ],
  "landing_url": "https://doi.org/10.1080/0886022x.2026.2745216",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Glomerulonephritis and Immunologic Disorders"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "lcc",
      "RC870-923"
    ],
    [
      "openalex",
      "2727|Renal Diseases and Glomerulopathies"
    ]
  ],
  "openalex": "W7223577257",
  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2026.2745216?needAccess=true",
  "pmcid": "PMC13715343",
  "pmid": "42928114",
  "published": "2026-10-25",
  "publisher": "Taylor & Francis Group",
  "ris": "https://research.draconitic.com/paper/anfvj9gjdwnm2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:17Z",
      "native_id": "0442971eb3ba4db8861b97b3107e7fe0",
      "source": "doaj",
      "url": "https://doi.org/10.1080/0886022x.2026.2745216"
    },
    {
      "first_seen": "2026-11-01T12:22:40Z",
      "native_id": "PMC13715343",
      "source": "pmc",
      "url": "https://doi.org/10.1080/0886022x.2026.2745216"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Renal Diseases and Glomerulopathies",
      "subfield": "general"
    }
  ],
  "title": "Clinical characteristics and prognosis of IgA nephropathy with predominant light chain deposition",
  "title_text": "Clinical characteristics and prognosis of IgA nephropathy with predominant light chain deposition",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:40Z",
  "url": "https://research.draconitic.com/paper/anfvj9gjdwnm2",
  "venue": "Renal Failure",
  "versions": []
}