{
  "abstract": "Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and memory loss, ultimately leading to a loss of independence and reduced quality of life. As current treatments are most effective in the early stages, reliable blood-based biomarkers are required for early diagnosis, therapeutic monitoring, and disease staging. Plasma neurofilament light chain (NfL), a marker of neuroaxonal injury, is a candidate biomarker; its value relative to established amyloid- and tau-based biomarkers is unclear. A systematic review and meta-analysis comparing plasma NfL with Aβ42, Aβ40, the Aβ42/Aβ40 ratio, and p-tau217 across cognitively normal (control, Con), mild cognitive impairment (MCI), and AD groups was conducted. Fourteen studies that met specific criteria were included. Plasma NfL and p-tau217 increased across disease stages. Aβ42 and Aβ42/Aβ40 were lower in AD/MCI than in Con; Aβ40 was similar across groups. Heterogeneity (I² < 99%) was observed across biomarkers. Plasma NfL reliably reflected neuroaxonal injury and disease severity from the earliest clinically detectable stage of AD. Plasma NfL may be most valuable when combined with p-tau217/Aβ-based assays to provide a more comprehensive, blood-based assessment of both AD-specific pathology and neurodegeneration. Further studies are needed to validate its prognostic utility and establish clinically applicable cut-off values.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nursing, College of Nursing, Gachon University, Incheon 21936, Republic of Korea.",
    "Neuroscience Research Institute, Gachon University, Incheon 21565, Republic of Korea.",
    "Bio-MAX Institute, Seoul National University, Seoul 08826, Republic of Korea.",
    "Department of Pharmacology, College of Medicine, Gachon University, Incheon 21999, Republic of Korea."
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ka Young Kim",
      "orcid": "0000-0003-3705-6449"
    },
    {
      "affs": [
        2
      ],
      "name": "Ki Young Shin"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Keun-A Chang",
      "orcid": "0000-0002-6157-6340"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ap78jhy7xdv41.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198574",
  "fulltext_url": "https://europepmc.org/articles/PMC13664730",
  "id": "ap78jhy7xdv41",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883821",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7214398163",
  "pdf_url": "https://europepmc.org/articles/PMC13664730?pdf=render",
  "pmcid": "PMC13664730",
  "pmid": "42883821",
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ap78jhy7xdv41.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883821",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883821"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Plasma Neurofilament Light Chain as a Complementary Biomarker for Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.",
  "title_text": "Plasma Neurofilament Light Chain as a Complementary Biomarker for Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/ap78jhy7xdv41",
  "venue": "International journal of molecular sciences",
  "versions": []
}