{
  "abstract": "Multivalent glycan recognition depends critically on the spatial organization of saccharides, yet quantitative design rules linking glycan geometry to binding remain poorly defined. Here, we report atomically-precise Fe(II)-based glycoassemblies that enable independent control of glycan valency, spacing, and topology within discrete molecular scaffolds. Using monomeric Griffithsin as a model lectin, we uncover that subtle changes in glycan presentation drive discrete transitions from partial site engagement to high-avidity, multi-site binding, spanning a > 10³-fold range in affinity. Structurally optimized assemblies achieve binding that surpass the binding strength of native high-mannose glycans, entering an effectively irreversible regime. These findings define geometric thresholds for intramolecular avidity and establish a framework for engineering multivalent ligands with programmable binding properties.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Emerson Hall"
    },
    {
      "name": "Yu-Shien Sung"
    },
    {
      "name": "Chad W. Priest"
    },
    {
      "name": "Julia M. Stauber",
      "orcid": "0000-0001-9783-907X"
    },
    {
      "name": "Alex J. Guseman",
      "orcid": "0000-0002-9796-5719"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/apb4fnvmx7p6q.bib",
  "cited_by": 0,
  "doi": "10.1038/s42004-026-02228-8",
  "fulltext_url": null,
  "id": "apb4fnvmx7p6q",
  "issns": [
    "2399-3669"
  ],
  "landing_url": "https://www.nature.com/articles/s42004-026-02228-8",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Carbohydrate Chemistry and Synthesis"
    ]
  ],
  "openalex": "W7221914472",
  "pdf_url": "https://www.nature.com/articles/s42004-026-02228-8_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/apb4fnvmx7p6q.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:51Z",
      "native_id": "10.1038/s42004-026-02228-8",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42004-026-02228-8"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Carbohydrate Chemistry and Synthesis",
      "subfield": "organic"
    }
  ],
  "title": "Structural control of Fe(II)-based multivalent glycan assemblies enables intramolecular avidity and ultra-high-affinity binding",
  "title_text": "Structural control of Fe(II)-based multivalent glycan assemblies enables intramolecular avidity and ultra-high-affinity binding",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:51Z",
  "url": "https://research.draconitic.com/paper/apb4fnvmx7p6q",
  "venue": "Communications Chemistry",
  "versions": []
}