{
  "abstract": "Reliable circulating biomarkers for prognosis and treatment monitoring in non-small cell lung cancer (NSCLC) remain limited. Liquid biopsy offers a minimally invasive approach to identify clinically informative tumour-derived markers. Given the emerging role of GalNAc-transferases in cancer biology, we evaluated GALNT13 expression in peripheral blood as a potential biomarker for prognosis and disease monitoring in lung cancer patients. Sensitive molecular assays (nested and digital RT-PCR) were developed to detect GALNT13 mRNA in circulating tumour cells (CTCs). These methods were applied to peripheral blood samples from non-small cell lung cancer patients to assess prognostic value and enable longitudinal monitoring. A cohort of 143 NSCLC patients was analysed, of whom 60% were GALNT13-positive in peripheral blood at baseline. During a five-year follow-up, GALNT13 positivity was significantly associated with reduced overall survival. In several patients, increases in GALNT13 levels preceded radiologic evidence of disease progression. GALNT13 expression in CTCs emerges as a promising biomarker for prognosis and treatment monitoring in NSCLC. Prospective studies in larger cohorts are warranted to validate its clinical utility.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratorio de Oncología Molecular, Servicio de Oncología, Hospital Maciel, Administración de Servicios de Salud del Estado (ASSE), 25 de Mayo 174, Montevideo 11000, Uruguay",
    "Laboratorio de Glicobiología e Inmunología Tumoral, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay",
    "Liquid Biopsy and Cancer Interception Group, Centre for Genomics and Oncological Research (GENyO), Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avenida de la Ilustración 114, 18016 Granada, Spain",
    "Pathological Anatomy Unit (UPIGAP), University Hospital Virgen de las Nieves, Av. de las Fuerzas Armadas 2, 18014 Granada, Spain",
    "Instituto de Investigación Biosanitaria ibs.GRANADA, Av. de Madrid 15, Beiro, 18012 Granada, Spain",
    "Servicio de Hemoterapia, Hospital Maciel, ASSE, 25 de Mayo 174, Montevideo 11000, Uruguay",
    "Departamento de Inmunobiología, Facultad de Medicina, Universidad de la República, Av. General Flores 2125, Montevideo 11800, Uruguay"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Eugenia Fernández Armúa",
      "orcid": "0000-0001-9087-397X"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "María José Serrano",
      "orcid": "0000-0003-0298-9054"
    },
    {
      "affs": [
        0
      ],
      "name": "Diego Santana",
      "orcid": "0009-0009-8408-1269"
    },
    {
      "affs": [
        0
      ],
      "name": "Mariana Carrasco",
      "orcid": "0000-0002-8888-0780"
    },
    {
      "affs": [
        2
      ],
      "name": "María Pilar Molina"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Inés Aznar",
      "orcid": "0000-0003-4902-214X"
    },
    {
      "affs": [
        0
      ],
      "name": "Marcos Acosta"
    },
    {
      "affs": [
        5
      ],
      "name": "Beatriz Villar",
      "orcid": "0009-0009-3328-762X"
    },
    {
      "affs": [
        5
      ],
      "name": "Juan Ferrari"
    },
    {
      "affs": [
        0
      ],
      "name": "Diego Touya"
    },
    {
      "affs": [
        0,
        1,
        6
      ],
      "name": "Eduardo Osinaga"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Nora Berois",
      "orcid": "0000-0002-6372-2540"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/apbhs05mw0wtr.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209095",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705257/?tool=EBI",
  "id": "apbhs05mw0wtr",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9095",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Cancer Genomics and Diagnostics"
    ]
  ],
  "openalex": "W7221794049",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705257/pdf/?tool=EBI",
  "pmcid": "PMC13705257",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/apbhs05mw0wtr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27209095",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9095"
    },
    {
      "first_seen": "2026-10-30T12:21:34Z",
      "native_id": "PMC:PMC13705257",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705257"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer Genomics and Diagnostics",
      "subfield": "oncology"
    }
  ],
  "title": "Circulating Tumour Cell GALNT13 Expression Is Associated with Prognosis and Treatment Response in Non-Small Cell Lung Cancer",
  "title_text": "Circulating Tumour Cell GALNT13 Expression Is Associated with Prognosis and Treatment Response in Non-Small Cell Lung Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:34Z",
  "url": "https://research.draconitic.com/paper/apbhs05mw0wtr",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}