{
  "abstract": "Aging is the major biological risk factor for cognitive decline and neurodegenerative disease. Increasing evidence indicates that neuroinflammation and cerebrovascular dysfunction are not independent consequences of aging but interact through the neurovascular interface. Cerebrovascular endothelial cells are central to this interaction because they form the blood–brain barrier (BBB) while actively regulating vascular tone, molecular transport, leukocyte trafficking, and inflammatory signaling. Here, we review how aging simultaneously primes immune and endothelial compartments through microglial sensitization, astrocytic remodeling, systemic inflammaging, endothelial senescence, altered transcytosis, oxidative stress, and senescence-associated inflammatory signaling. Immune-derived cytokines, reactive oxygen species, matrix metalloproteinases, complement signals, and inflammasome-related pathways can impair endothelial homeostasis, whereas aged endothelial cells relay systemic inflammatory signals through adhesion molecules, chemokines, complement receptors, and altered barrier transport. These reciprocal interactions can destabilize BBB function, cerebral blood flow regulation, and the broader neurovascular unit. Importantly, physiological aging should not be equated with neurodegenerative disease; rather, it may establish a compensated but vulnerable immune–endothelial state that is amplified by disease-specific modifiers. We discuss competing immune-first, vascular-first, and parallel-aging models and evaluate emerging therapeutic strategies aimed at restoring neurovascular homeostasis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Geriatrics, The First Hospital of Jilin University",
    "Department of Neurology, The First Hospital of Jilin University",
    "Department of Neurology, Beijing Tiantan Hospital, Capital Medical University",
    "Human Brain and Tissue Bank, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhitao Cui"
    },
    {
      "affs": [
        1
      ],
      "name": "Huaiyu Sun"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Zhiqing Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiaai Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/apdx5x9wtc27s.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1972284",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725442/?tool=EBI",
  "id": "apdx5x9wtc27s",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1972284/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Mini Review"
    ],
    [
      "openalex",
      "2808|Barrier Structure and Function Studies"
    ]
  ],
  "openalex": "W7222970572",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1972284/pdf",
  "pmcid": "PMC13725442",
  "pmid": "42974162",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/apdx5x9wtc27s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1972284",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1972284/full"
    },
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13725442",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13725442"
    },
    {
      "first_seen": "2026-11-04T12:23:50Z",
      "native_id": "PMC13725442",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1972284"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42974162",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974162"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Barrier Structure and Function Studies",
      "subfield": "neurology"
    }
  ],
  "title": "Immune-endothelial crosstalk at the nexus of neuroinflammation and vascular dysfunction in aging",
  "title_text": "Immune-endothelial crosstalk at the nexus of neuroinflammation and vascular dysfunction in aging",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:42Z",
  "url": "https://research.draconitic.com/paper/apdx5x9wtc27s",
  "venue": "Frontiers in Immunology",
  "versions": []
}