{ "abstract": "A distinct proportion of patients with atopic dermatitis and dupilumab treatment does not reach the primary endpoint of an eczema area severity index (EASI)-75 or investigator global assessment 0/1 after 16 weeks. Little is known about poor responders to dupilumab in real life scenarios. The study objective was to identify the percentage and characteristics of patients with insufficient treatment response to dupilumab based on “TREATgermany” registry data from dermatological routine care. Between 06/2016 and 12/2024, 476 patients matched the study criteria. In total, 4% of patients (n=19) were identified as dupilumab poor responders, i.e. reduction in EASI ≤40% at the 1st follow-up visit after 8 to 20 weeks and a consecutive 2nd follow-up visit up to 52 weeks of treatment. 44% (n=209) were classified as stable responders, i.e. decrease in EASI≥75% at both follow-up visits. Poor responders were significantly more often male, more frequently exhibited smoking, arterial hypertension and a higher body mass index. This TREATgermany data analysis demonstrates a proportion of 4% dupilumab poor responders within the first year of treatment. Male sex, smoking, arterial hypertension and increased body mass index were identified as potential risk factors. Further translational research is needed to confirm these clinical findings.", "abstract_shown": true, "affiliations": [ "Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany", "Center for Evidence-Based Healthcare, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany", "Hannover Medical School, Cluster of Excellence RESIST (EXC 2155), Hannover, Germany", "Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany", "Clinic for Dermatology, University Hospital, Mainz, Germany", "Thomas Schaefer, MVZ Derma Köln, Cologne, Germany", "Department of Dermatology, Carl Gustav Carus Faculty of Medicine, TUD Dresden University of Technology, Dresden, Germany", "University Allergy Center (UAC), University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany", "Institute for Health Services Research in Dermatology Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany", "Practice 'Die Hautärzte' Braunschweig, Braunschweig, Germany", "Department of Dermatology, Venereology and Allergology, Clinical Research, University Hospital, Frankfurt am Main, Germany", "Practice Kathrin Meinhardt, Beckum, Germany", "Dermatology Clinic, Helix Medical Excellence Center Mainz, Mainz, Germany", "Practice Dr. med. Sabine Anders, Munich, Germany", "Practice Dr. med. Beate Schwarz, Langenau, Germany", "Practice Dr. med. Michael Schulz-Kiesow and Dr. med. Inken Reimers, Lübeck, Germany", "Hohenzollernring Dermatology Practice, Münster, Germany", "Hautärzte am Fastnachtsbrunnen, FÄ Nicole Adler, Mainz, Germany", "Practice Dr. med. Christiane Handrick, Berlin, Germany", "Department of Dermatology, University Hospital, Heidelberg, Germany", "Department of Dermatology, University, German Center for Immunotherapy, Erlangen, Germany", "Practice Dr. med. Anne Bong, Emmerich, Germany", "Practice DERMAKULM, Kulmbach, Germany", "Practice Dr. med. Bernd Großmann, Koblenz, Germany", "Practice Dr. med. Maren Stahl, Osterode, Germany", "Skin and laser medicine Kinzigtal, Practice Dr. med. Bürkle, Haslach, Germany", "Practice Dermasana, Karlsruhe, Germany", "Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, Munich, Germany" ], "article_type": "research article", "arxiv": null, "author_total": 36, "authors": [ { "affs": [ 0 ], "name": "Annice Heratizadeh", "orcid": "0000-0002-9231-9865" }, { "affs": [ 0 ], "name": "Joëlle Naim", "orcid": "0009-0001-0084-6554" }, { "affs": [ 1 ], "name": "Barbara Kind", "orcid": "0009-0002-5254-6411" }, { "affs": [ 1 ], "name": "Katharina Loennecke", "orcid": "0009-0000-5565-0615" }, { "affs": [ 0 ], "name": "Sascha Fischer" }, { "affs": [ 0 ], "name": "Tatjana Honstein", "orcid": "0009-0001-2897-964X" }, { "affs": [ 0, 2 ], "name": "Stephan Traidl", "orcid": "0000-0003-4806-599X" }, { "affs": [ 0 ], "name": "Eva Moennig" }, { "affs": [ 1 ], "name": "Thomas Birkner", "orcid": "0000-0002-1027-7295" }, { "affs": [ 3 ], "name": "Inken Harder", "orcid": "0000-0002-3079-0440" }, { "affs": [ 4 ], "name": "Caroline Mann" }, { "affs": [ 5 ], "name": "Thomas Schaefer" }, { "affs": [ 6, 7 ], "name": "Susanne Abraham", "orcid": "0000-0001-7457-6481" }, { "affs": [ 8 ], "name": "Matthias Augustin", "orcid": "0000-0002-4026-8728" }, { "affs": [ 9 ], "name": "Jutta Ramaker-Brunke" }, { "affs": [ 10 ], "name": "Andreas Pinter", "orcid": "0000-0002-1330-1502" }, { "affs": [ 11 ], "name": "Kathrin Meinhardt", "orcid": "0009-0005-7826-5353" }, { "affs": [ 12 ], "name": "Sven Quist" }, { "affs": [ 13 ], "name": "Sabine Anders" }, { "affs": [ 14 ], "name": "Beate Schwarz" }, { "affs": [ 15 ], "name": "Michael Schulz-Kiesow" }, { "affs": [ 16 ], "name": "Sabine Steinke" }, { "affs": [ 17 ], "name": "Nicole Adler" }, { "affs": [ 18 ], "name": "Christiane Handrick" }, { "affs": [ 19 ], "name": "Knut Schäkel", "orcid": "0000-0001-6344-7799" }, { "affs": [ 20 ], "name": "Michael Sticherling", "orcid": "0000-0001-9396-3938" }, { "affs": [ 21 ], "name": "Anne Bong" }, { "affs": [ 22 ], "name": "Felix Jacobs" }, { "affs": [ 23 ], "name": "Bernd Großmann" }, { "affs": [ 24 ], "name": "Maren Stahl" }, { "affs": [ 25 ], "name": "Carl-Philipp Buerkle" }, { "affs": [ 26 ], "name": "Hannah Gorriahn-Maiterth" }, { "affs": [ 27 ], "name": "Tilo Biedermann", "orcid": "0000-0002-5352-5105" }, { "affs": [ 3 ], "name": "Stephan Weidinger", "orcid": "0000-0003-3944-252X" }, { "affs": [ 1 ], "name": "Jochen Schmitt", "orcid": "0000-0003-0264-0960" }, { "affs": [ 0, 2 ], "name": "Thomas Werfel", "orcid": "0000-0001-6830-7672" } ], "bibtex": "https://research.draconitic.com/paper/apekw1d2ch4fn.bib", "cited_by": 0, "doi": "10.2340/actadv.v106.adv-2026-0806", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738001/", "id": "apekw1d2ch4fn", "issns": [ "0001-5555", "1651-2057" ], "landing_url": "https://doi.org/10.2340/actadv.v106.adv-2026-0806", "language": "en", "licence": "CC-BY-NC-4.0", "licence_label": "CC BY-NC 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Atopy, Allergy and Eczema" ], [ "heading", "Original Report" ], [ "openalex", "2708|Dermatology and Skin Diseases" ] ], "openalex": "W7225320587", "pdf_url": "https://medicaljournalssweden.se/actadv/article/download/47169/56042", "pmcid": "PMC13738001", "pmid": "42986187", "published": "2026-11-05", "publisher": "MJS Publishing", "ris": "https://research.draconitic.com/paper/apekw1d2ch4fn.ris", "sources": [ { "first_seen": "2026-11-09T12:23:04Z", "native_id": "PMC13738001", "source": "pmc", "url": "https://doi.org/10.2340/actadv.v106.adv-2026-0806" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2708|Dermatology and Skin Diseases", "subfield": "general" } ], "title": "Dupilumab in Atopic Dermatitis – Rate of Poor Responders and Potential Risk Factors from the TREATgermany Registry", "title_text": "Dupilumab in Atopic Dermatitis – Rate of Poor Responders and Potential Risk Factors from the TREATgermany Registry", "type": "peer-reviewed", "updated_at": "2026-11-09T12:23:04Z", "url": "https://research.draconitic.com/paper/apekw1d2ch4fn", "venue": "Acta Dermato-Venereologica", "versions": [] }