{
  "abstract": "Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication and interaction, and by restricted or repetitive behaviors. The study aimed to evaluate the neuroprotective potential of a phenolic extract of Passiflora edulis (EPE) on social behavior and neurochemical markers in a murine model of ASD induced by valproic acid (VPA). Pregnant female BALB/c mice (Mus musculus) were exposed to VPA (600 mg/kg on day 12.5 of gestation), and the offspring of both sexes were subsequently treated with EPE at doses of 50, 100, or 300 mg/kg for forty two days. The EPE was characterized by UHPLC-MS/MS, identifying vicenin-2, isoschaftoside, isoorientin, vitexin-2″-O-rhamnoside, and isovitexin. Behavioral assessments included locomotion, stereotypy, anxiety, social interaction, and memory. Biochemical analyses covered antioxidant enzymes (CAT, SOD, GPx) and mRNA expression of GluA1- and GluA2 AMPA receptor subunits. The results demonstrated a significant improvement in social behavior with a normalization of GluA1 subunit expression at 300 mg/kg. In conclusion, these findings suggest that phenolic compounds from Passiflora edulis ameliorate social deficits in the ASD model through modulation of glutamatergic signaling-specifically via GluA1 subunit RNA expression-mediated CAT and SOD antioxidant activity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacology, Faculty of Pharmacy and Biochemistry, Universidad Nacional de Trujillo, Trujillo 13011, Peru",
    "Pharmacology of Natural Products Group, Universidad Nacional de Trujillo, Trujillo 13011, Peru",
    "Laboratory of Natural Product Pharmacology, Faculty of Pharmacy and Biochemistry, Universidad Nacional de Trujillo, Trujillo 13011, Peru",
    "Faculty of Pharmacy and Biochemistry, Universidad Nacional de Trujillo, Trujillo 13011, Peru",
    "Department of Pharmacotechnics, Faculty of Pharmacy and Biochemistry, Universidad Nacional de Trujillo, Trujillo 13011, Peru",
    "Biochemistry Laboratory, Department of Biochemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional de Trujillo, Trujillo 13011, Peru",
    "Molecular Processes and Translational Health Research Group, Biochemistry Laboratory, Department of Biochemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional de Trujillo, Trujillo 13011, Peru",
    "Centro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9170020, Chile"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Betsabé Chunga-Flores",
      "orcid": "0000-0002-5346-2853"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Lucia Fátima Flores-Atoche",
      "orcid": "0000-0003-1661-7593"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Gianfranco Ramos-Farfán",
      "orcid": "0009-0003-3696-3247"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Gladys Galliani-Huamanchumo",
      "orcid": "0000-0002-8590-1881"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Cristian Junior Paredes-Barros",
      "orcid": "0009-0003-1080-6104"
    },
    {
      "affs": [
        3
      ],
      "name": "Alejandrina Llaure-Mora"
    },
    {
      "affs": [
        4
      ],
      "name": "Felipe Rubén Rubio López"
    },
    {
      "affs": [
        4
      ],
      "name": "Edmundo A. Venegas-Casanova",
      "orcid": "0000-0001-9284-9180"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Jesús Guzmán",
      "orcid": "0000-0002-4366-0258"
    },
    {
      "affs": [
        7
      ],
      "name": "Rafael Barra",
      "orcid": "0000-0002-2898-3729"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Julio Campos-Florián",
      "orcid": "0000-0003-0930-4169"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aphbwknvwpger.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31213876",
  "fulltext_url": null,
  "id": "aphbwknvwpger",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/21/3876",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2805|Autism Spectrum Disorder Research"
    ]
  ],
  "openalex": "W7223956293",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/aphbwknvwpger.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.3390/molecules31213876",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/21/3876"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Autism Spectrum Disorder Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "Phenolic Compounds from Passiflora edulis and Their Effect on Social Behavior and the AMPA Receptor in a Preclinical Model of Autism",
  "title_text": "Phenolic Compounds from Passiflora edulis and Their Effect on Social Behavior and the AMPA Receptor in a Preclinical Model of Autism",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:42Z",
  "url": "https://research.draconitic.com/paper/aphbwknvwpger",
  "venue": "Molecules",
  "versions": []
}