{
  "abstract": "The regio- and enantioselective functionalization of gaseous alkanes remains an unsolved challenge in organic synthesis. Here, we report a general strategy for the asymmetric three-component dicarbofunctionalization of alkenes using readily available gaseous alkanes, including ethane, propane, and isobutane. This transformation, enabled by the merger of hydrogen atom transfer photocatalysis with a chiral nickel catalyst, efficiently delivers chiral α-aryl carbonyl compounds in good yield with excellent regio- and enantioselectivity (up to >20:1 rr and 99:1 er). Experimental and computational studies reveal insights into the mechanism controlling selectivity. Operating under exceptionally mild, energy-efficient conditions, the method unlocks a versatile platform for upgrading feedstock gaseous alkanes into sought-after chiral building blocks.",
  "abstract_shown": true,
  "affiliations": [
    "Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago de Compostela15782, Spain.",
    "Department of Chemistry, University of Zurich, Winterthurerstrasse 190, ZurichCH 8057, Switzerland.",
    "Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California90095, United States.",
    "Oportunius, Galician Innovation Agency (GAIN), Santiago de Compostela15702, Spain."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sergio Barbeira-Arán"
    },
    {
      "affs": [
        0
      ],
      "name": "Akshay M Nair"
    },
    {
      "affs": [
        0
      ],
      "name": "Jose M Malga"
    },
    {
      "affs": [
        1
      ],
      "name": "Xia Hu",
      "orcid": "0000-0002-2995-2369"
    },
    {
      "affs": [
        2
      ],
      "name": "Ángel Rentería-Gómez",
      "orcid": "0000-0002-9411-8805"
    },
    {
      "affs": [
        2
      ],
      "name": "Yaning Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Achyut R Gogoi"
    },
    {
      "affs": [
        2
      ],
      "name": "Osvaldo Gutierrez"
    },
    {
      "affs": [
        1
      ],
      "name": "Cristina Nevado",
      "orcid": "0000-0002-3297-581X"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Martín Fañanás-Mastral",
      "orcid": "0000-0003-4903-0502"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aps7p6c23rnff.bib",
  "cited_by": 0,
  "doi": "10.1021/jacs.6c15886",
  "fulltext_url": "https://europepmc.org/articles/PMC13693456",
  "id": "aps7p6c23rnff",
  "issns": [
    "0002-7863",
    "1520-5126"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912347",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7221076825",
  "pdf_url": "https://europepmc.org/articles/PMC13693456?pdf=render",
  "pmcid": "PMC13693456",
  "pmid": "42912347",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aps7p6c23rnff.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42912347",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912347"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Regio- and Enantioselective Functionalization of Gaseous Alkanes via Nickel-Catalyzed Alkene Dicarbofunctionalization.",
  "title_text": "Regio- and Enantioselective Functionalization of Gaseous Alkanes via Nickel-Catalyzed Alkene Dicarbofunctionalization.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/aps7p6c23rnff",
  "venue": "Journal of the American Chemical Society",
  "versions": []
}